| Effect of clinical status and treatment on the frequency of CD5+ B cells in patients with myasthenia gravis. | |
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MedLine Citation:
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PMID: 1374546 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CD5+ B cells comprise a subset of B lymphocytes that may play a pathogenetic role in the development of human autoimmune disease. We previously reported a high-frequency phenotype (greater than 30% CD5+ B cells) in the peripheral blood of 57% of myasthenia gravis (MG) patients and 13% of controls. We have now examined additional patients (n = 41) and controls (n = 27) and continue to find that 44% of MG patients have a high-frequency phenotype of CD5+ B cells compared with 7% of controls. Serial studies showed that the frequency of CD5+ B cells in peripheral blood remained fairly stable for controls and that it may decrease with immunosuppressive therapy of MG patients. In patients receiving anticholinesterase only or no therapy (n = 21), the age at onset of MG, presence or absence of detectable serum anti-acetylcholine receptor antibody, clinical extent of MG, and the duration of disease may affect the frequency of CD5+ B cells in the blood. |
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Authors:
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S Ragheb; R P Lisak |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Neurology Volume: 42 ISSN: 0028-3878 ISO Abbreviation: Neurology Publication Date: 1992 May |
Date Detail:
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Created Date: 1992-06-09 Completed Date: 1992-06-09 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0401060 Medline TA: Neurology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1076-80 Citation Subset: AIM; IM |
Affiliation:
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Department of Neurology, Wayne State University, Detroit, MI. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antigens, CD / blood* Antigens, CD5 Autoantibodies / blood B-Lymphocytes / immunology* Chi-Square Distribution Female Humans Immunophenotyping Male Myasthenia Gravis / immunology*, therapy |
| Grant Support | |
ID/Acronym/Agency:
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CA 22453/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD; 0/Antigens, CD5; 0/Autoantibodies |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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