Document Detail


Effect of clinical status and treatment on the frequency of CD5+ B cells in patients with myasthenia gravis.
MedLine Citation:
PMID:  1374546     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CD5+ B cells comprise a subset of B lymphocytes that may play a pathogenetic role in the development of human autoimmune disease. We previously reported a high-frequency phenotype (greater than 30% CD5+ B cells) in the peripheral blood of 57% of myasthenia gravis (MG) patients and 13% of controls. We have now examined additional patients (n = 41) and controls (n = 27) and continue to find that 44% of MG patients have a high-frequency phenotype of CD5+ B cells compared with 7% of controls. Serial studies showed that the frequency of CD5+ B cells in peripheral blood remained fairly stable for controls and that it may decrease with immunosuppressive therapy of MG patients. In patients receiving anticholinesterase only or no therapy (n = 21), the age at onset of MG, presence or absence of detectable serum anti-acetylcholine receptor antibody, clinical extent of MG, and the duration of disease may affect the frequency of CD5+ B cells in the blood.
Authors:
S Ragheb; R P Lisak
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neurology     Volume:  42     ISSN:  0028-3878     ISO Abbreviation:  Neurology     Publication Date:  1992 May 
Date Detail:
Created Date:  1992-06-09     Completed Date:  1992-06-09     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1076-80     Citation Subset:  AIM; IM    
Affiliation:
Department of Neurology, Wayne State University, Detroit, MI.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antigens, CD / blood*
Antigens, CD5
Autoantibodies / blood
B-Lymphocytes / immunology*
Chi-Square Distribution
Female
Humans
Immunophenotyping
Male
Myasthenia Gravis / immunology*,  therapy
Grant Support
ID/Acronym/Agency:
CA 22453/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Antigens, CD; 0/Antigens, CD5; 0/Autoantibodies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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