Document Detail

Effect of clentiazem on lipid profile, lipoprotein composition and aortic fatty streaks in cholesterol-fed rabbits.
MedLine Citation:
PMID:  1759985     Owner:  NLM     Status:  MEDLINE    
Numerous experimental studies have reported that common antihypertensive drugs such as diuretics, beta-blockers, and methyldopa have adverse effects on plasma lipids and lipoproteins. The present study was designed to define the effect of clentiazem (10 mg/kg/day) an antihypertensive drug, on hyperlipidemia in rabbits on a cholesterol-rich diet (1%) for 12 weeks. Compared with controls, clentiazem treated rabbits had lower plasma concentrations of triglycerides (55%), total cholesterol (24%), free cholesterol (27%), esterified cholesterol (23%) and phospholipids (24%). The decrease in cholesterol was accounted for by a reduction of VLDL-cholesterol (13%), IDL-cholesterol (24%) and primarily LDL-cholesterol (45%). Neither HDL-cholesterol nor chemical composition of VLDL, IDL, LDL and HDL was altered. When the aortic atherosclerotic involvement was evaluated by computerized planimetry, a 24% reduction of lesions was noted in clentiazem treated animals (P less than 0.05). Similarly, cholesterol content extracted from aortic wall was decreased. Our data therefore demonstrated that clentiazem is a potential antiatherosclerotic agent capable of decreasing plasma lipids and atherogenic lipoproteins as well as aortic fatty streaks.
E Levy; J Tardif; P Russo; F Lavigne; L Thibault; J St-Louis; C Garofalo; M Bendayan; D Bouthillier; D Garceau
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Atherosclerosis     Volume:  90     ISSN:  0021-9150     ISO Abbreviation:  Atherosclerosis     Publication Date:  1991 Oct 
Date Detail:
Created Date:  1992-02-05     Completed Date:  1992-02-05     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  141-8     Citation Subset:  IM    
Department of Nutrition, University of Montreal, Québec, Canada.
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MeSH Terms
Antihypertensive Agents / pharmacology*
Aorta / metabolism,  pathology
Aortic Diseases / blood*,  metabolism,  pathology
Arteriosclerosis / blood*,  metabolism,  pathology
Cholesterol / blood
Cholesterol, Dietary / administration & dosage*
Diltiazem / analogs & derivatives*,  pharmacology
Lipid Metabolism
Lipids / blood*
Lipoproteins / chemistry*
Triglycerides / blood
Reg. No./Substance:
0/Antihypertensive Agents; 0/Cholesterol, Dietary; 0/Lipids; 0/Lipoproteins; 0/Triglycerides; 111659-76-8/clentiazem; 42399-41-7/Diltiazem; 57-88-5/Cholesterol

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