Document Detail


Effect of cladribine treatment on beta-2 microglobulin and soluble intercellular adhesion molecule 1 (ICAM-1) in patients with multiple sclerosis.
MedLine Citation:
PMID:  11552664     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
beta-2 Microglobulin (beta 2M) is a low molecular weight protein located extracellularly and associated with class 1 antigens of the major histocompatibility complex and is considered a marker for disease activity in immune disorders. Cladribine (2-chloro-2-deoxyadenosine, 2-CDA) is a potent lymphocytotoxic agent under investigation in the treatment in MS patients. As beta 2M levels may indicate inflammatory events in CNS we determined CSF-beta 2M and serum beta 2M levels in patients with relapsing-remitting MS before and after cladribine treatment as well as in a control group. There was a significant beta 2M decrease in sera but not in CSF in MS patients after the cladribine treatment, associated with a slight but significant clinical improvement measured by Kurtzke's Expanded Disability Status Scale. We also found a significant decrease in sICAM-1 level in CSF but not in sera in MS patients. The data support a role of cladribine in MS therapy and deliver new information on cladribine immunological effects in MS patients.
Authors:
A Niezgoda; J Losy; P D Mehta
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Folia morphologica     Volume:  60     ISSN:  0015-5659     ISO Abbreviation:  Folia Morphol. (Warsz)     Publication Date:  2001 Aug 
Date Detail:
Created Date:  2001-09-12     Completed Date:  2001-10-04     Revised Date:  2006-06-23    
Medline Journal Info:
Nlm Unique ID:  0374620     Medline TA:  Folia Morphol (Warsz)     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  225-8     Citation Subset:  IM    
Affiliation:
Department of Clinical Neuroimmunology, University School of Medicine, ul. Przybyszewskiego 49, 60-355 Poznań, Poland.
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MeSH Terms
Descriptor/Qualifier:
Adult
Cladribine / administration & dosage*
Female
Humans
Immunosuppressive Agents / administration & dosage*
Intercellular Adhesion Molecule-1 / blood*,  cerebrospinal fluid
Male
Middle Aged
Multiple Sclerosis / blood,  cerebrospinal fluid,  drug therapy*
Solubility
beta 2-Microglobulin / blood*,  cerebrospinal fluid
Chemical
Reg. No./Substance:
0/Immunosuppressive Agents; 0/beta 2-Microglobulin; 126547-89-5/Intercellular Adhesion Molecule-1; 4291-63-8/Cladribine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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