| Effect of citrus lemon oil on growth and adherence of Streptococcus mutans. | |
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MedLine Citation:
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PMID: 23381618 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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In order to exploit novel anticaries agents, we investigated the effects of citrus lemon oil (CLO), a type of natural product, on growth and adherence of the primary oral cariogenic bacteria Streptococcus mutans (S. mutans). The growth inhibitory effect was explored with a micro-dilution assay. Adherence was analyzed by colony counts on the respective surfaces and the adherence inhibition rate (AIR). Real time-PCR was used to investigate the effects of CLO on transcription of glucosyltransferase (Gtf) encoding genes, gtfB, C and D. Neson-Somogyi method was used to measure the effects of CLO on Gtf activity. The minimum inhibitory concentration of CLO against S. mutans was 4.5 mg/ml. The CLO effectively reduced the adherence of S. mutans on glass surface (the AIR were from 98.3 to 100 %, P > 0.05) and saliva-coated enamel surface (the AIR were from 54.8 to 79.2 %, P < 0.05). CLO effectively reduced the activity of Gtf and the transcription of gtfs in a dose dependent manner (P < 0.05). In conclusion, CLO can effectively inhibit the growth and the adherence to glass and saliva-coated enamel surfaces of S. mutans. It can also inhibit the transcription of gtfs, as well as the Gtf enzyme activity. |
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Authors:
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Ying Liu; Xiangyu Zhang; Yuzhi Wang; Feifei Chen; Zhifen Yu; Li Wang; Shuanglu Chen; Maoding Guo |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-2-5 |
Journal Detail:
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Title: World journal of microbiology & biotechnology Volume: - ISSN: 1573-0972 ISO Abbreviation: World J. Microbiol. Biotechnol. Publication Date: 2013 Feb |
Date Detail:
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Created Date: 2013-2-5 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9012472 Medline TA: World J Microbiol Biotechnol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Tianjin Medical University Stomatological Hospital, No. 12, Qixiangtai Road, Heping District, Tianjin, 300070, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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