Document Detail

Effect of cisapride on secondary peristalsis in patients with gastroesophageal reflux disease.
MedLine Citation:
PMID:  10086669     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Improvement of esophageal acid clearance appears to be an important effect of cisapride in the treatment of reflux disease. The mechanism underlying this effect is not clear. Esophageal peristalsis is a major component of the acid clearance process. In normal subjects secondary peristalsis is an important mechanism of esophageal acid clearance during sleep, and this response appears to be impaired in patients with reflux esophagitis. The effects of cisapride on secondary peristalsis are not known. The aim of this study was to investigate the effects of cisapride on the triggering and characteristics of secondary peristalsis in patients with reflux esophagitis. METHODS: In 17 patients with reflux esophagitis and impaired secondary peristalsis cisapride, 10 mg q.i.d., or placebo were administered in a randomized double blind, crossover design for 4 days separated by a 4-7 day washout period. On the fourth day of treatment, primary peristalsis and secondary peristalsis in response to 10- and 20-ml air boluses were assessed. RESULTS: Secondary peristaltic success and amplitude were greater with the 20-ml bolus than with the 10-ml bolus. However, cisapride had no effect on either secondary peristaltic success or amplitude. Cisapride also had no effect on primary peristalsis or basal LES pressure. CONCLUSIONS: The improvement in esophageal acid clearance by cisapride is not explainable by improvement in secondary peristalsis.
R H Holloway; R Penagini; M N Schoeman; J Dent
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of gastroenterology     Volume:  94     ISSN:  0002-9270     ISO Abbreviation:  Am. J. Gastroenterol.     Publication Date:  1999 Mar 
Date Detail:
Created Date:  1999-04-01     Completed Date:  1999-04-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0421030     Medline TA:  Am J Gastroenterol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  799-803     Citation Subset:  IM    
Department of Gastrointestinal Medicine, Royal Adelaide Hospital, South Australia.
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MeSH Terms
Cisapride / adverse effects,  pharmacokinetics,  therapeutic use*
Cross-Over Studies
Double-Blind Method
Esophagitis, Peptic / drug therapy*,  physiopathology
Esophagus / physiopathology
Gastrointestinal Agents / adverse effects,  pharmacokinetics,  therapeutic use*
Middle Aged
Peristalsis / drug effects*
Reg. No./Substance:
0/Gastrointestinal Agents; 81098-60-4/Cisapride
Comment In:
Am J Gastroenterol. 2000 Feb;95(2):552-3   [PMID:  10685771 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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