Document Detail

Effect of cisapride on the gastro-oesophageal function in normal human subjects.
MedLine Citation:
PMID:  3653529     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to investigate oesophageal peristalsis and gastro-oesophageal function in normal subjects after 4 days of cisapride 10 mg p.o. 3 times/day and 10 mg 1.5 h before the investigation. The study was carried out in a double-blind cross-over design with coded cisapride or placebo tablets. Basal sphincter pressure increased after cisapride (p less than 0.002). The peristaltic pressure amplitude in the oesophageal body as well as the duration and velocity of the peristaltic pressure wave were measured after wet swallows. No changes were found. Intragastric pH was unchanged after cisapride. No effect was found on the result of a standard acid clearing test. Plasma concentration of cisapride did not correlate with any of the other variables. Oral cisapride increases fasting gastro-oesophageal sphincter pressure, but does not influence oesophageal peristalsis, acid clearing or intragastric pH in normal subjects.
L Wallin; S Kruse-Andersen; T Madsen; S Boesby
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Digestion     Volume:  37     ISSN:  0012-2823     ISO Abbreviation:  Digestion     Publication Date:  1987  
Date Detail:
Created Date:  1987-11-05     Completed Date:  1987-11-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0150472     Medline TA:  Digestion     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  160-5     Citation Subset:  IM    
Department of Thoracic and Cardiovascular Surgery T, Odense University Hospital, Denmark.
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MeSH Terms
Double-Blind Method
Esophagogastric Junction / drug effects*,  physiology
Esophagus / physiology*
Gastric Emptying / drug effects
Peristalsis / drug effects
Piperidines / pharmacology*
Stimulation, Chemical
Reg. No./Substance:
0/Piperidines; 81098-60-4/Cisapride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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