Document Detail

Effect of cisapride on gastric sensitivity to distension, gastric compliance and duodeno-gastric reflexes in healthy humans.
MedLine Citation:
PMID:  11529652     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND AIMS: Visceral hypersensitivity and impaired gastric relaxation after the ingestion of a meal are frequent features in patients with functional dyspepsia. Cisapride improves dyspeptic symptoms. The study aims to evaluate whether cisapride influences gastric sensitivity to distension as well as gastric compliance and duodenogastric reflexes. PATIENTS AND METHODS: Eight healthy males were studied on two different days, each after 7 days' treatment either with placebo or cisapride 10 mg qid in randomized order. A spherical bag connected to a barostat was placed in the gastric fundus and an 8-lumen manometric catheter was positioned with 4 side holes in antrum and 4 in duodenum. During a phase II of the migrating motor complex, the intragastric bag was inflated at a constant pressure 1 mm Hg above the intra-abdominal pressure and the gastric volume was measured during intraduodenal infusion of lipids and citric acid at different rates. Once the stomach returned to the basal volume, the bag was distended according to two different protocols until subjects reported discomfort. Antroduodenal motility was measured throughout the study. RESULTS: Intraduodenal infusion of lipids and citric acid caused relaxation of gastric fundus. Relaxation was similar for lipids and acid (203 +/- 30 vs 199 +/- 43 ml), and was not influenced by cisapride and infusion rate. Cisapride did not influence gastric sensitivity to distension (10 +/- 1.5 vs 9.7 +/- 1.3 mm Hg) and gastric compliance (52.7 +/- 1.2 vs 49.8 +/- 1.8 ml/mm Hg). The antral motor index significantly decreased following infusion of acid and lipids with placebo but not with cisapride. CONCLUSIONS: Cisapride inhibits the physiological duodenoantral reflexes but does not influence either the mechanical properties of the gastric fundus nor the gastric sensitivity to distension.
G Manes; J E Domínguez-Muñoz; A Leodolter; P Malfertheiner
Publication Detail:
Type:  Clinical Trial; Comparative Study; Evaluation Studies; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver     Volume:  33     ISSN:  1590-8658     ISO Abbreviation:  Dig Liver Dis     Publication Date:    2001 Jun-Jul
Date Detail:
Created Date:  2001-08-31     Completed Date:  2002-01-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100958385     Medline TA:  Dig Liver Dis     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  407-13     Citation Subset:  IM    
Department of Gastroenterology, Cardarelli Hospital, Napoli, Italy.
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MeSH Terms
Cisapride / pharmacology*
Duodenum / drug effects*,  physiology*
Gastric Emptying / drug effects*,  physiology*
Gastrointestinal Agents / pharmacology*
Gastrointestinal Motility / drug effects*,  physiology*
Muscle Relaxation / drug effects*,  physiology*
Reference Values
Sensitivity and Specificity
Sensory Thresholds / drug effects,  physiology
Stomach / drug effects*,  physiology*
Treatment Outcome
Reg. No./Substance:
0/Gastrointestinal Agents; 81098-60-4/Cisapride

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