Document Detail

Effect of cisapride on gastric emptying in premature infants with feed intolerance.
MedLine Citation:
PMID:  11903835     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess the effect of cisapride on gastric emptying and gastro-oesophageal reflux (GOR) symptoms in preterm infants with feed intolerance. METHODS: Sixteen preterm infants (gestational age 24-35 weeks) with feed intolerance were enrolled in the study. Infants were randomized to receive 7 days of cisapride 0.2 mg/kg four times a day, immediately followed by 7 days of placebo or vice versa. Gastric emptying was measured using the [13C]-octanoic acid breath test prior to study entry and repeated on day 5, 6 or 7 after randomization and 5, 6 or 7 days after crossover. The symptoms of GOR were monitored during the study period using a standardized reflux chart. Weight was recorded daily. RESULTS: There was no change in gastric emptying in infants prescribed cisapride (gastric half-emptying time (t1/2) 31.9 +/- 4.7 vs 34.2 +/- 3.9 min for placebo vs cisapride, respectively; P = 0.65). Infants on cisapride had slower growth and there was no change in reflux symptoms. CONCLUSIONS: The use of cisapride in preterm infants with feed intolerance cannot be recommended.
C P Barnett; T Omari; G P Davidson; L Goodchild; R Lontis; J Dent; R R Haslam
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of paediatrics and child health     Volume:  37     ISSN:  1034-4810     ISO Abbreviation:  J Paediatr Child Health     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2002-03-20     Completed Date:  2002-04-23     Revised Date:  2007-09-24    
Medline Journal Info:
Nlm Unique ID:  9005421     Medline TA:  J Paediatr Child Health     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  559-63     Citation Subset:  IM    
Neonatal Medicine Unit, Women's and Children's Hospital, North Adelaide, Australia.
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MeSH Terms
Breath Tests
Cisapride / administration & dosage*
Cross-Over Studies
Dose-Response Relationship, Drug
Drug Administration Schedule
Enteral Nutrition / methods
Feeding and Eating Disorders of Childhood / drug therapy*
Follow-Up Studies
Gastric Emptying / drug effects*
Gastrointestinal Agents / administration & dosage*
Infant, Newborn
Infant, Premature, Diseases / drug therapy*
Reference Values
Treatment Outcome
Reg. No./Substance:
0/Gastrointestinal Agents; 81098-60-4/Cisapride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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