Document Detail


Effect of cirrhosis at baseline on the outcome of type 1 autoimmune hepatitis.
MedLine Citation:
PMID:  22166568     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
MATERIAL AND METHODS: With the aim of analyzing the influence of presence of cirrhosis at baseline on the outcome, we revised the evolution of a cohort of patients with type 1 autoimmune hepatitis, prospectively followed at a single hospital. 139 patients (113 females, 26 males), median age 45.7 years, interquartile range 13-59 years, were followed-up for a median period of 58 months (interquartile range 27-106).
RESULTS: At baseline, 55 patients had cirrhosis and they were significantly older, had lower prothrombin activity and serum albumin than patients without cirrhosis. In contrast, patients without cirrhosis had significantly higher bilirubin, AST and ALT levels at diagnosis time. There was no significant difference in the follow-up time between patients with and without cirrhosis at baseline and either in the percentage of patients receiving immunosupresor treatment (80 vs. 91%, respectively) or in the response to therapy (complete response in 82 vs. 95%, respectively). However, patients with cirrhosis had a significantly lower probability of remaining free of cirrhosis complications (49.1% at 102 months, 95%CI, 35.5-67.9% vs. 86.7%, 95%CI, 77.1%-97.5%, respectively) (p = 0.0000) and a significantly lower overall survival at 120 months (67.1%, 95%CI, 51.3-87.6 vs. 94.4%, 95%CI, 86.9-100%, respectively) (p = 0.003) than those without cirrhosis at presentation.
CONCLUSION: Patients with type 1 autoimmune hepatitis and cirrhosis at presentation have a lower survival than those without cirrhosis despite a similar response to treatment.
Authors:
Graciela Landeira; Silvia Morise; Eduardo Fassio; Margarita Ramonet; Estela Alvarez; Patricia Caglio; Cristina Longo; Nora Domínguez
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of hepatology     Volume:  11     ISSN:  1665-2681     ISO Abbreviation:  Ann Hepatol     Publication Date:    2012 Jan-Feb
Date Detail:
Created Date:  2011-12-14     Completed Date:  2012-06-12     Revised Date:  2013-05-16    
Medline Journal Info:
Nlm Unique ID:  101155885     Medline TA:  Ann Hepatol     Country:  Mexico    
Other Details:
Languages:  eng     Pagination:  100-6     Citation Subset:  IM    
Affiliation:
Liver Unit, Hospital Nacional Profesor Alejandro Posadas, El Palomar, Provincia de Buenos Aires, Argentina.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Biopsy
Cohort Studies
Disease Progression
Female
Follow-Up Studies
Hepatitis, Autoimmune / drug therapy*,  mortality*
Humans
Immunosuppressive Agents / therapeutic use*
Liver / pathology
Liver Cirrhosis / complications*,  pathology
Male
Middle Aged
Prospective Studies
Retrospective Studies
Survival Rate
Treatment Outcome
Young Adult
Chemical
Reg. No./Substance:
0/Immunosuppressive Agents

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