Document Detail

Effect of circadian rhythm on bronchomotor tone after deep inspiration in normal and in asthmatic subjects.
MedLine Citation:
PMID:  3896077     Owner:  NLM     Status:  MEDLINE    
Bronchomotor tone after deep inspiration and bronchial responsiveness to methacholine were studied at 4:00 A.M. and 4:00 P.M. in 14 normal and 13 asthmatic subjects. Bronchomotor tone was assessed with respiratory resistance (Rrs) measured by the forced oscillation method. Bronchial responsiveness to methacholine and baseline Rrs were higher at 4:00 A.M. than at 4:00 P.M. in both normal and asthmatic subjects (p less than 0.01). The difference in methacholine threshold between 4:00 P.M. and 4:00 A.M. In asthmatics was similar to that in normal subjects. Immediately after deep inspiration, Rrs decreased more at 4:00 A.M. than at 4:00 P.M. In normal subjects. In contrast, asthmatic subjects showed a significantly greater immediate increase in Rrs after deep inspiration at 4:00 A.M. than at 4:00 P.M. It is suggested that the bronchoconstrictive effect after deep inspiration is a distinguishing characteristic of asthmatics.
Y N Liu; H Sasaki; M Ishii; K Sekizawa; W Hida; M Ichinose; T Takishima
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American review of respiratory disease     Volume:  132     ISSN:  0003-0805     ISO Abbreviation:  Am. Rev. Respir. Dis.     Publication Date:  1985 Aug 
Date Detail:
Created Date:  1985-09-12     Completed Date:  1985-09-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370523     Medline TA:  Am Rev Respir Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  278-82     Citation Subset:  AIM; IM    
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MeSH Terms
Airway Resistance* / drug effects
Asthma / physiopathology*
Bronchi / physiology*,  physiopathology
Bronchial Provocation Tests
Catecholamines / blood
Circadian Rhythm*
Heart Rate
Methacholine Chloride
Methacholine Compounds / diagnostic use
Middle Aged
Reg. No./Substance:
0/Catecholamines; 0/Methacholine Compounds; 62-51-1/Methacholine Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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