| Effect of ciprofloxacin on the pharmacokinetics and pharmacodynamics of warfarin. | |
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MedLine Citation:
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PMID: 8838180 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To determine if ciprofloxacin therapy alters the response to warfarin treatment, 36 adult patients attending three university-affiliated outpatient anticoagulation clinics randomly received a 12-day course of ciprofloxacin (750 mg twice daily) and a 12-day course of placebo; each course was separated by a 2-week washout period. Prothrombin times (PTs), concentrations of S-warfarin and R-warfarin (the isomers of warfarin), and concentrations of clotting factors II and VII were determined three times weekly for 9 weeks. By day 12 of ciprofloxacin therapy, concentrations of S-warfarin remained unchanged compared with those after placebo therapy, but R-warfarin concentrations increased significantly (1.15 times those after placebo therapy; P = .001); concentrations of clotting factors II and VII decreased (0.903 and 0.872 times those after placebo therapy, respectively, P < or = .020). The mean PT ratio after 12 days of ciprofloxacin therapy increased slightly (1.032 times that after placebo therapy; P = .057), but no patient had bleeding or a change in PT that required alteration in warfarin or ciprofloxacin therapy. We conclude that warfarin therapy is not a contraindication to the use of ciprofloxacin. |
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Authors:
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D S Israel; J Stotka; W Rock; C D Sintek; A K Kamada; C Klein; W R Swaim; R E Pluhar; J P Toscano; J T Lettieri; A H Heller; R E Polk |
Publication Detail:
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Type: Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America Volume: 22 ISSN: 1058-4838 ISO Abbreviation: Clin. Infect. Dis. Publication Date: 1996 Feb |
Date Detail:
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Created Date: 1996-12-03 Completed Date: 1996-12-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9203213 Medline TA: Clin Infect Dis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 251-6 Citation Subset: IM |
Affiliation:
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Department of Pharmacy and Pharmaceutics, Virginia Commonwealth University, Richmond 23298, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Anti-Infective Agents / pharmacology* Anticoagulants / pharmacokinetics*, therapeutic use Ciprofloxacin / pharmacology* Double-Blind Method Drug Interactions Factor VII / analysis Female Humans Male Middle Aged Prothrombin / analysis Prothrombin Time Warfarin / pharmacokinetics*, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Anti-Infective Agents; 0/Anticoagulants; 81-81-2/Warfarin; 85721-33-1/Ciprofloxacin; 9001-25-6/Factor VII; 9001-26-7/Prothrombin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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