Document Detail


Effect of cimetidine on serum uric acid concentration.
MedLine Citation:
PMID:  6697675     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of cimetidine therapy on serum uric acid concentration was studied in four healthy men with normal renal function. Beginning four days before the 16-day study, subjects were permitted no beverages containing caffeine or alcohol and no medications and were placed on a weight-maintenance, isocaloric, purine-free 152-meq-sodium diet. On days 1-12 one cimetidine 300-mg tablet was taken four times daily; on days 13-16 no cimetidine was taken. On each study day, serum uric acid and creatinine and urine uric acid and creatinine concentrations were determined. Daily mean values for serum uric acid, total uric acid excreted, and uric acid clearance were not significantly different from baseline. No significant change occurred in creatinine excreted or creatinine clearance. Cimetidine administration to healthy men with normal renal function did not significantly affect serum uric acid concentration or renal clearance of urate.
Authors:
R R Berardi; M L Hyneck; I A Cohen; L A Cornish; S R Achem
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Clinical pharmacy     Volume:  3     ISSN:  0278-2677     ISO Abbreviation:  Clin Pharm     Publication Date:    1984 Jan-Feb
Date Detail:
Created Date:  1984-04-11     Completed Date:  1984-04-11     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8207437     Medline TA:  Clin Pharm     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  56-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Cimetidine / pharmacology*
Creatinine / metabolism
Humans
Male
Time Factors
Uric Acid / blood*,  urine
Grant Support
ID/Acronym/Agency:
507RR05571-18/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
51481-61-9/Cimetidine; 60-27-5/Creatinine; 69-93-2/Uric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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