Document Detail


Effect of cigarette smoking on extent of acid-secreting area and intestinal metaplasia in the stomach.
MedLine Citation:
PMID:  3338356     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The association of cigarette smoking and other variables with the extent of the acid-secreting area and intestinal metaplasia were investigated by multivariate analysis. Studies were made by the endoscopic Congo red-methylene blue test developed in our hospital. In this test, acid-secreting areas and areas of intestinal metaplasia could be identified as discolored areas and areas staining blue with methylene blue, respectively. In multivariate analysis, the following variables were associated with a reduction in the size of the acid-secreting area in decreasing order of importance: the smoking index and age. The following factors had little or no influence on the size of the acid-secreting area: sex, and the consumption of aspirin and nonsteroidal, nonsalicylate, antiinflammatory drugs (NSNSAIDs). In general, in patients with a high smoking index, the acid-secreting area was small. Smoking had an influence in both younger and older patients and had more influence in females than in males. Multivariate analysis also shows that the following factors were associated with an increase in the area of intestinal metaplasia in decreasing order of importance: the extent of the acid-secreting area, age, and the smoking index. The following factors had little or no influence on the area of intestinal metaplasia: the consumption of aspirin and NSNSAIDs and sex. In general, in patients with little or no acid-secreting area, the area of intestinal metaplasia was extensive. These findings indicate that smoking is associated with reduction in the size of the acid-secreting area and so in development of intestinal metaplasia.
Authors:
M Tatsuta; H Iishi; S Okuda
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  33     ISSN:  0163-2116     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  1988 Jan 
Date Detail:
Created Date:  1988-03-10     Completed Date:  1988-03-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  23-9     Citation Subset:  AIM; IM    
Affiliation:
Department of Gastrointestinal Oncology, Center for Adult Diseases, Osaka, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Age Factors
Aged
Aged, 80 and over
Anti-Inflammatory Agents / adverse effects
Chronic Disease
Female
Gastric Acid / secretion*
Gastric Mucosa / pathology*,  physiopathology
Gastritis / etiology,  pathology,  physiopathology*
Humans
Male
Metaplasia
Middle Aged
Smoking / adverse effects*,  physiopathology
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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