Document Detail

Effect of cigarette smoking on copper, lead, and cadmium accumulation in human lens.
MedLine Citation:
PMID:  9613387     Owner:  NLM     Status:  MEDLINE    
AIM: To identify cigarette smoking as a risk factor for development of cataract, to determine the importance of copper, lead, and cadmium in cataractogenesis, and to learn about any relation between those elements. METHODS: Copper, lead, and cadmium concentrations were measured by atomic absorption spectrophotometry in 37 cataractous and nine normal human lenses. RESULTS: All three element accumulations in lenses with cataract were statistically meaningful. Lenticular copper, lead, and cadmium were increased significantly with cigarette smoking. Cadmium had a positive correlation both with lead and copper in cataractous lenses. CONCLUSION: The accumulation of copper, lead, and cadmium occurs in cataract. The probable source of cadmium in humans is cigarettes. Lenticular cadmium accumulation also increases copper and lead precipitation in the lens. Cigarette smoking might be cataractogenic.
O Cekic
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The British journal of ophthalmology     Volume:  82     ISSN:  0007-1161     ISO Abbreviation:  Br J Ophthalmol     Publication Date:  1998 Feb 
Date Detail:
Created Date:  1998-06-11     Completed Date:  1998-06-11     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0421041     Medline TA:  Br J Ophthalmol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  186-8     Citation Subset:  IM    
Department of Ophthalmology, University of Ankara Medical School, Turkey.
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MeSH Terms
Cadmium / analysis*
Case-Control Studies
Cataract / etiology*
Copper / analysis*
Lead / analysis*
Lens, Crystalline / chemistry*
Middle Aged
Risk Factors
Smoking / adverse effects*
Spectrophotometry, Atomic
Statistics, Nonparametric
Reg. No./Substance:
7439-92-1/Lead; 7440-43-9/Cadmium; 7440-50-8/Copper

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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