| Effect of cicloxilic acid on bile lipid composition in patients with gallstones: a multicenter trial. | |
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MedLine Citation:
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PMID: 6360773 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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24 gallstone patients were treated with cicloxilic acid, an agent endowed with choleretic activity, at the dose of 240 mg/day for 1 month. 24 comparable patients on placebo treatment acted as controls. Bile lipid composition was determined and the saturation index calculated before and after treatment, on samples collected by duodenal siphonage after caerulein stimulation, in both groups. In the cicloxilic group there was little or no change in bile salts and phospholipids, whereas biliary cholesterol concentration was significantly reduced (p less than 0.05) and consequently the lithogenic index lowered (from 1.5 to 1.2, p less than 0.01). Cicloxilic acid can have a place in gallstone disease therapy in association with the litholytic bile acids or in the prevention of gallstone formation in high-risk populations. |
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Authors:
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N Carulli; M Ponz de Leon; M Podda; C Di Padova; M Zuin |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Digestion Volume: 28 ISSN: 0012-2823 ISO Abbreviation: Digestion Publication Date: 1983 |
Date Detail:
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Created Date: 1984-02-14 Completed Date: 1984-02-14 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0150472 Medline TA: Digestion Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 102-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Bile / analysis* Caerulein / diagnostic use Cholelithiasis / drug therapy, metabolism* Cholesterol / analysis Clinical Trials as Topic Cyclohexanecarboxylic Acids / pharmacology*, therapeutic use Double-Blind Method Female Humans Lipids / analysis* Male Middle Aged Phospholipids / analysis Random Allocation |
| Chemical | |
Reg. No./Substance:
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0/Cyclohexanecarboxylic Acids; 0/Lipids; 0/Phospholipids; 17650-98-5/Caerulein; 57-88-5/Cholesterol; 57808-63-6/cicloxilic acid |
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