Document Detail

Effect of chymase on intraocular pressure in rabbits.
MedLine Citation:
PMID:  16253233     Owner:  NLM     Status:  MEDLINE    
Chymase is a chymotrypsin-like serine protease that is stored exclusively in the secretory granules of mast cells and converts big endothelins to endothelin-1 (1-31). The aim of this study was to evaluate the effect of chymase on intraocular pressure in rabbits. Chymase injection (3 and 10 mU) resulted in a trend toward increased intraocular pressure and a significant increase in intraocular pressure at a dose of 10 mU compared with the control. A specific chymase inhibitor, Suc-Val-Pro-Phe(P)(OPh)(2), attenuated the ocular hypertension induced by chymase. Endothelin-1 (1-31) also caused ocular hypertension, which was inhibited by a selective endothelin ET(A) receptor antagonist, cyclo(D-Asp-Pro-D-Val-Leu-D-Trp) (BQ-123). Moreover, chymase-induced ocular hypertension was inhibited by BQ-123. These results suggest that chymase influences the regulation of intraocular pressure, and it is likely that the formation of endothelin-1 (1-31) and subsequent activation of endothelin ET(A) receptors are involved in the development of ocular hypertension induced by chymase.
Takashi Konno; Midori Maruichi; Shinji Takai; Hidehiro Oku; Tetsuya Sugiyama; Takehiro Uchibori; Akihiko Nagai; Kentaro Kogi; Tsunehiko Ikeda; Mizuo Miyazaki
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2005-10-25
Journal Detail:
Title:  European journal of pharmacology     Volume:  524     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-11-18     Completed Date:  2006-01-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  132-7     Citation Subset:  IM    
Drug Research Section II, Fukushima Research Laboratories, Yuno, Iizaka-machi, Fukushima City, Fukushima, Japan.
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MeSH Terms
Antihypertensive Agents / pharmacology
Dose-Response Relationship, Drug
Endothelin-1 / administration & dosage,  analogs & derivatives
Enzyme Inhibitors / pharmacology
Intraocular Pressure / drug effects*,  physiology
Oligopeptides / pharmacology
Peptide Fragments / administration & dosage
Peptides, Cyclic / pharmacology
Receptors, Endothelin / antagonists & inhibitors
Recombinant Proteins / administration & dosage
Serine Endopeptidases / administration & dosage*,  genetics
Time Factors
Reg. No./Substance:
0/Antihypertensive Agents; 0/Endothelin-1; 0/Enzyme Inhibitors; 0/Oligopeptides; 0/Peptide Fragments; 0/Peptides, Cyclic; 0/Receptors, Endothelin; 0/Recombinant Proteins; 0/endothelin-1 (1-31); 0/succinyl-valyl-prolyl-phenylalanyl-diphenylphosphonate; 136553-81-6/cyclo(Trp-Asp-Pro-Val-Leu); EC 3.4.21.-/Serine Endopeptidases; EC

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