Document Detail

Effect of chronic stress in the blood pressure in the rat: ACTH administration.
MedLine Citation:
PMID:  2843449     Owner:  NLM     Status:  MEDLINE    
We have studied the effect of chronic noise stress (St) and ACTH administration (Ac) affecting blood pressure and plasma corticosterone levels in male Wistar rats. Both chronic treatments elicited an increase in plasma corticosterone and blood pressure levels. The blood pressure increased from the first week of treatment period in St and Ac rats and remained high 4 weeks after the end of the stress period. However, blood pressure elevation decrease progressively during the first three weeks of post-treatment in ACTH administrated rats. The rise of blood pressure levels was due to the effect of chronic treatment. This was demonstrated by the absence of differences between the two values of blood pressure measurement with and without daily treatment in both St and Ac groups. Increased corticosterone levels decreased rapidly during the post-treatment period in St and Ac rats. The results suggest a possible relationship between the development of hypertension and the Hypothalamus-Hypophysis-adrenal (HHA) axis stimulation in rats.
A Gamallo; P Alario; M A Villanúa; M P Nava
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme     Volume:  20     ISSN:  0018-5043     ISO Abbreviation:  Horm. Metab. Res.     Publication Date:  1988 Jun 
Date Detail:
Created Date:  1988-10-17     Completed Date:  1988-10-17     Revised Date:  2009-02-19    
Medline Journal Info:
Nlm Unique ID:  0177722     Medline TA:  Horm Metab Res     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  336-8     Citation Subset:  IM    
Dept. Fisiologia Animal, Fac.Biologia, Universidad Complutense, Madrid, Spain.
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MeSH Terms
Adrenocorticotropic Hormone / pharmacology*
Blood Pressure* / drug effects
Blood Pressure Determination
Corticosterone / blood
Hypothalamo-Hypophyseal System / physiology
Rats, Inbred Strains
Stress, Physiological / physiopathology*
Reg. No./Substance:
50-22-6/Corticosterone; 9002-60-2/Adrenocorticotropic Hormone

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