Document Detail


Effect of chronic propranolol treatment on bone changes of secondary hyperparathyroidism in dialysis patients.
MedLine Citation:
PMID:  7177287     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To assess the effect of long-term propranolol therapy on uremic osteodystrophy, we evaluated retrospectively the biochemical, X-ray, and bone histological changes in 9 dialysed hypertensives who had been on propranolol treatment for periods ranging from 1 to 8 years. The control group included 9 well-matched dialysed uremics never treated with beta-blockers. The two groups did not differ in serum ionized calcium or iPTH levels. The incidence of bone resorption evaluated on X-ray findings and on bone biopsy specimens was of a comparable degree in the two groups. Our data show that propranolol even if started early in the course of renal failure, is of no benefit in preventing uremic bone disease.
Authors:
F Pizzarelli; C Zoccali; C Ciccarelli; Q Maggiore; E Bonucci; P Ballanti
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nephron     Volume:  32     ISSN:  0028-2766     ISO Abbreviation:  Nephron     Publication Date:  1982  
Date Detail:
Created Date:  1983-02-14     Completed Date:  1983-02-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0331777     Medline TA:  Nephron     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  93-4     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Bone Resorption / drug effects
Humans
Hyperparathyroidism, Secondary / drug therapy*
Kidney Failure, Chronic / complications*,  therapy
Propranolol / therapeutic use*
Renal Dialysis*
Renal Osteodystrophy / drug therapy*
Chemical
Reg. No./Substance:
525-66-6/Propranolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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