Document Detail

Effect of chronic preoptic lesions on the renal excretion of sodium in rats.
MedLine Citation:
PMID:  1155604     Owner:  NLM     Status:  MEDLINE    
Rats with bilateral lesions in the preoptic area showed a normal pattern of urineand electrolyte excretion under resting conditions but complete absence of a natriuretic response to unilateral carotid baroreceptor stimulation and also a significant reduction in the rate of sodium excretion after saline loading and after a high-sodium intake. Measurements of renal clearance did not show any significant differences in glomerular filtration rate, renal plasma flow, or filtration fraction between normal and preoptic-lesion rats. Apart from the test situations used above, rats with preoptic lesions were apparently able to regulate their sodium metabolism normally because after 3 wk on a high-sodium intake their plasma and extracellular fluid volumes, plasma electrolytes, osmolaity, and mean arterial pressures were indistinguishable from normal rats. It is suggested that the preoptic component of the baroreceptor reflex pathway mighthave an input into a hypothalamic area controlling sodium excretion.
R Keeler
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of physiology     Volume:  228     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1975 Jun 
Date Detail:
Created Date:  1975-11-08     Completed Date:  1975-11-08     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1725-8     Citation Subset:  IM    
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MeSH Terms
Blood Pressure
Blood Proteins / metabolism
Blood Volume
Carotid Sinus / physiology
Extracellular Space / physiology
Glomerular Filtration Rate
Hypothalamus / physiology*
Kidney / blood supply
Kidney Medulla / metabolism
Osmolar Concentration
Plasma Volume
Potassium / blood,  urine
Preoptic Area / physiology*
Regional Blood Flow
Sodium / blood
Sodium Chloride / pharmacology
Reg. No./Substance:
0/Blood Proteins; 7440-09-7/Potassium; 7440-23-5/Sodium; 7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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