Document Detail

Effect of chronic intake of arsenic-contaminated water on blood oxidative stress indices in cattle in an arsenic-affected zone.
MedLine Citation:
PMID:  20655591     Owner:  NLM     Status:  MEDLINE    
This study aimed to determine the hemato-biochemical picture and blood oxidative stress in zebu cattle in an arsenic-contaminated zone. Significant decline in total erythrocyte count, packed cell volume, and total plasma protein was observed in cattle of that area in comparison to uncontaminated zone. There was significant elevation of plasma enzyme activities of both alanine aminotransaminase and aspertate aminotransaminase. Increased corpuscular osmotic fragility also proved to be a mechanism for deviation from normal functioning of erythrocytes. Cattle in the affected zone showed a significantly higher arsenic burden in blood. Those animals further showed decreased superoxide dismutase, catalase activities of erythrocytes, and plasma nitrite level, but increased lipid peroxidation and protein carbonyl level. Our finding concluded that cattle of the arsenic-contaminated zone is suffering from a subclinical form of arsenic toxicity, which is proved through altered hemato-biochemical indices and a certain extent of oxidative stress with higher arsenic concentration in blood.
Tanmoy Rana; Asit Kumar Bera; Subhashree Das; Debasis Bhattacharya; Subhasish Bandyopadhyay; Diganta Pan; Subrata Kumar Das
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-07-23
Journal Detail:
Title:  Ecotoxicology and environmental safety     Volume:  73     ISSN:  1090-2414     ISO Abbreviation:  Ecotoxicol. Environ. Saf.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-06     Completed Date:  2010-12-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7805381     Medline TA:  Ecotoxicol Environ Saf     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1327-32     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 Elsevier Inc. All rights reserved.
Indian Veterinary Research Institute, Eastern Regional Station, 37, Belgachia Road, Kolkata 700 037, India.
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MeSH Terms
Alanine Transaminase / blood
Arsenic / analysis,  blood,  toxicity*
Arsenic Poisoning / blood*,  enzymology,  metabolism,  veterinary
Aspartate Aminotransferases / blood
Blood Proteins / analysis
Cattle Diseases / blood*,  enzymology,  metabolism
Erythrocytes / enzymology
Lipid Peroxidation / drug effects
Oxidative Stress / drug effects*
Water Pollutants, Chemical / analysis,  blood,  toxicity*
Reg. No./Substance:
0/Blood Proteins; 0/Water Pollutants, Chemical; 7440-38-2/Arsenic; EC Aminotransferases; EC Transaminase

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