Document Detail

Effect of chronic infusion of synthetic atrial natriuretic factor (ANF 8-33) in conscious two-kidney, one-clip hypertensive rats.
MedLine Citation:
PMID:  3880894     Owner:  NLM     Status:  MEDLINE    
Conscious two-kidney, one-clip hypertensive rats were chronically infused during 7 days with synthetic ANF (8-33) (1 microgram/hr/rat) by means of osmotic minipumps. The initial blood pressure of 183 +/- 4 mmHg gradually decreased to 116 +/- 5 mmHg the last 2 days of infusion. Pressure diuresis returned to normal and pressure natriuresis was attenuated. PRA was significantly lower (1.81 +/- 0.41 AI ng/ml/hr) than in not treated hypertensive rats (8.56 +/- 3.75 AI ng/ml/hr). A partial regression in cardiac hypertrophy was observed in the treated group. We suggest that the hypotensive response to ANF may be mainly due to vasodilatation, but the possibility that the decrease in PRA may play a partial role in lowering blood pressure, cannot be excluded.
R Garcia; G Thibault; J Gutkowska; P Hamet; M Cantin; J Genest
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)     Volume:  178     ISSN:  0037-9727     ISO Abbreviation:  Proc. Soc. Exp. Biol. Med.     Publication Date:  1985 Jan 
Date Detail:
Created Date:  1985-02-20     Completed Date:  1985-02-20     Revised Date:  2007-11-02    
Medline Journal Info:
Nlm Unique ID:  7505892     Medline TA:  Proc Soc Exp Biol Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  155-9     Citation Subset:  IM    
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MeSH Terms
Atrial Natriuretic Factor*
Blood Pressure / drug effects
Diuresis / drug effects
Hormones / administration & dosage,  pharmacology*
Hypertension / physiopathology*
Infusions, Parenteral
Kidney / drug effects,  physiopathology*
Muscle Proteins / administration & dosage,  pharmacology*
Natriuresis / drug effects
Peptide Fragments / administration & dosage,  pharmacology*
Rats, Inbred Strains
Renin / blood
Reg. No./Substance:
0/Hormones; 0/Muscle Proteins; 0/Peptide Fragments; 85637-73-6/Atrial Natriuretic Factor; 91421-87-3/atrial natriuretic factor prohormone (8-33); EC

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