Document Detail

Effect of chronic oxidative/corticosterone-induced stress on ascorbic acid metabolism and total antioxidant capacity in chickens (Gallus gallus domesticus).
MedLine Citation:
PMID:  17615008     Owner:  NLM     Status:  MEDLINE    
The consequences of chronic corticosterone-induced stress (CCIS) on ascorbic acid (AsA) metabolism in chickens, an animal that syntheses the vitamin, are not known. This study was conducted to determine whether CCIS alters AsA synthesis, as measured by l-gulonolactone oxidase (GLO) activity, tissue AsA, lipid peroxides and tissue total antioxidant capacity (TAC). Stress was induced by dietary administration of corticosterone from 2 to 4 weeks of age and measurements were made at 0, 7 and 14 days post-treatment. Ascorbic acid synthesis was not influenced by CCIS but hepatic, cardiac, renal, bursal and duodenal AsA concentrations were significantly decreased and plasma TAC and uric acid concentrations were significantly elevated. Stress caused significant hepatomegaly and hepatic lipidosis but hepatic peroxides were not elevated despite the slight decrease in hepatic TAC. Tissue TAC varied in different organs. It was markedly elevated in the kidney, reduced by 49% in the spleen, and changes were not detected in the heart and duodenum even though AsA concentration was significantly decreased in all tissues. We conclude that CCIS caused a significant reduction in tissue AsA concentration but did not inhibit GLO activity. The change in AsA concentration was associated with increase, decrease or no change in TAC in tissues examined. The findings suggest that CCIS may alter AsA recycling, influx or turnover in different tissues of chickens.
D Maurice; S F Lightsey; J E Toler; S Canty
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of animal physiology and animal nutrition     Volume:  91     ISSN:  0931-2439     ISO Abbreviation:  J Anim Physiol Anim Nutr (Berl)     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-07-06     Completed Date:  2007-09-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101126979     Medline TA:  J Anim Physiol Anim Nutr (Berl)     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  355-60     Citation Subset:  IM    
Department of Animal and Veterinary Sciences, Clemson University, Clemson, SC 29634-0311, USA.
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MeSH Terms
Animal Feed
Antioxidants / metabolism*
Ascorbic Acid / biosynthesis,  metabolism*
Chickens / metabolism*
Corticosterone / administration & dosage,  pharmacology
Duodenum / drug effects,  metabolism
Heart / drug effects
L-Gulonolactone Oxidase / metabolism
Lipid Peroxidation / drug effects
Liver / drug effects,  metabolism
Myocardium / metabolism
Organ Specificity
Oxidative Stress*
Random Allocation
Spleen / drug effects,  metabolism
Tissue Distribution
Reg. No./Substance:
0/Antioxidants; 50-22-6/Corticosterone; 50-81-7/Ascorbic Acid; EC Oxidase

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