Document Detail

Effect of chronic ethanol administration on plasma levels of LH and the estrous cycle in the female rat.
MedLine Citation:
PMID:  7018298     Owner:  NLM     Status:  MEDLINE    
Intragastric intubation of 4 or 8 g/kg of body weight of ethanol per day for 12 consecutive days disrupted the normal estrous cycle in female rats as monitored by vaginal epithelial cell changes. Plasma luteinizing hormone levels were unchanged suggesting that blood ethanol in the 50--100 mg/100 ml range acted as a direct gonadal toxin and not at the hypothalamic-pituitary gland level.
R L Eskay; R S Ryback; M Goldman; E Majchrowicz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Alcoholism, clinical and experimental research     Volume:  5     ISSN:  0145-6008     ISO Abbreviation:  Alcohol. Clin. Exp. Res.     Publication Date:  1981  
Date Detail:
Created Date:  1981-08-10     Completed Date:  1981-08-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7707242     Medline TA:  Alcohol Clin Exp Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  204-6     Citation Subset:  IM    
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MeSH Terms
Alcoholism / blood*,  physiopathology
Epithelium / drug effects
Estrus / drug effects*
Gonadotropins / metabolism
Luteinizing Hormone / blood*
Sexual Behavior, Animal / drug effects
Vagina / drug effects
Reg. No./Substance:
0/Gonadotropins; 9002-67-9/Luteinizing Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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