Document Detail

Effect of chronic coffee consumption on aortic stiffness and wave reflections in hypertensive patients.
MedLine Citation:
PMID:  17164828     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Aortic stiffness and wave reflections are important markers and prognosticators of cardiovascular risk. Caffeine increases acutely aortic stiffness and wave reflections. Furthermore, chronic coffee consumption is associated with increased aortic stiffness and wave reflections in normotensive subjects. In the present study, we aimed to assess the association between chronic coffee consumption, and aortic stiffness and wave reflections in hypertensive patients. DESIGN: Epidemiological survey. SETTING: Hypertension Unit, University Hospital. SUBJECTS-METHODS: We examined 259 never-treated hypertensives (age 50+/-12 years, 165 males) without diabetes mellitus, who were asked to describe in detail the type and amount of coffee they consumed. Carotid-femoral pulse wave velocity (PWV) and augmentation index (AIx) were measured non-invasively as indices of aortic stiffness and wave reflections, respectively. RESULTS: When controlled for gender, age, height, smoking status, heart rate, mean pressure, HDL cholesterol and hsCRP, AIx was found to be higher with increasing daily coffee consumption. Post hoc analysis revealed that all groups of coffee consumption had higher AIx compared to no-consumption. PWV did not differ among groups of daily coffee consumption. Each participant had 35% higher relative risk of having high AIx for each cup (150 ml) of coffee per day, and 40% higher relative risk for each 10 cup-years. CONCLUSIONS: Coffee consumption is associated with increased wave reflections, but not aortic stiffness in never-treated hypertensive patients. This finding may have important clinical implications for cardiovascular health in hypertensive subjects.
C V Vlachopoulos; G G Vyssoulis; N A Alexopoulos; A I Zervoudaki; P G Pietri; K A Aznaouridis; C I Stefanadis
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Publication Detail:
Type:  Journal Article     Date:  2006-12-13
Journal Detail:
Title:  European journal of clinical nutrition     Volume:  61     ISSN:  0954-3007     ISO Abbreviation:  Eur J Clin Nutr     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-06-01     Completed Date:  2007-07-09     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8804070     Medline TA:  Eur J Clin Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  796-802     Citation Subset:  IM    
Hypertension Unit, 1st Cardiology Department, Athens Medical School, Hippokration Hospital, Athens, Greece.
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MeSH Terms
Aorta / drug effects*
Aortic Diseases / etiology*
Blood Flow Velocity
Blood Pressure
Caffeine / administration & dosage,  adverse effects
Central Nervous System Stimulants / administration & dosage,  adverse effects
Coffee* / adverse effects
Elasticity / drug effects
Hypertension / physiopathology*
Middle Aged
Pulsatile Flow / drug effects*,  physiology
Reg. No./Substance:
0/Central Nervous System Stimulants; 0/Coffee; 58-08-2/Caffeine

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