| Effect of chronic cervical ganglionectomy on the spontaneous variability of internal carotid blood flow in the conscious rat. | |
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MedLine Citation:
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PMID: 22308161 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The role of sympathetic innervation in the control of spontaneous fluctuations of cerebral blood flow is still poorly understood. In conscious, unrestrained rats, blood flow velocity (pulsed Doppler) was measured in both internal carotid arteries one week after either excision of the right superior cervical ganglion (n = 8) or sham surgery (n = 6). Using Fourier-based techniques, spectral power of each carotid blood flow (CBF) was computed over the whole recording period (246 min) that was segmented into 9 consecutive 27.3-min periods. Variability of CBF (spectral power) was ~40% higher (P < 0.02) on the denervated than on the intact side at frequencies < 1 Hz. Coherence between left and right CBFs was similar in the 2 groups of rats, except in the 0.01-0.1 Hz frequency range where it was lower (P < 0.05) in rats with unilateral sympathectomy (0.54 ± 0.03) as compared with intact (0.74 ± 0.06) rats. In this frequency range, mathematically removing the influence of arterial pressure had little effect on coherence between CBFs in both groups of rats so that coherence remained significantly lower in rats with unilateral sympathectomy (0.52 ± 0.03) than in intact (0.70 ± 0.06) rats. This study indicates that sympathetic innervation has an overall buffering influence on CBF variability. This modulating role is especially important in a frequency range corresponding to slow fluctuations of CBF (lasting from 10 to 100 s) which are essentially unrelated to fluctuations of AP. |
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Authors:
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Aurélia Revel; Clément Gallet; Valérie Oréa; Bruno Chapuis; Christian Barrès; Claude Julien |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-3 |
Journal Detail:
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Title: Experimental physiology Volume: - ISSN: 1469-445X ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-2-6 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9002940 Medline TA: Exp Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Université Claude Bernard Lyon 1. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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