| Effect of chronic caloric restriction on physiological variables related to energy metabolism in the male Fischer 344 rat. | |
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MedLine Citation:
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PMID: 2661930 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the present study, a number of physiological and behavioral measures that are related to metabolism were continuously monitored in 19-month-old male Fischer 344 rats that were fed ad libitum or fed a caloric restricted diet. Caloric restricted rats ate fewer meals but consumed more food during each meal and spent more time eating per meal than did rats fed ad libitum. Therefore, the timing and duration of meals as well as the total number of calories consumed may be associated with life extension. Average body temperature per day was significantly lower in restricted rats but body temperature range per day and motor activity were higher in restricted rats. Dramatic changes in respiratory quotient, indicating rapid changes in metabolic pathway and lower temperature, occurred in caloric restricted rats when carbohydrate reserves were depleted. Lower body temperature and metabolism during this time interval may result in less DNA damage, thereby increasing the survival potential of restricted rats. Nighttime feeding was found to synchronize physiological performance between ad libitum and caloric restricted rats better than daytime feeding, thereby allowing investigators to distinguish the effects of caloric restriction from those related solely to the time-of-day of feeding. |
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Authors:
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P H Duffy; R J Feuers; J A Leakey; K Nakamura; A Turturro; R W Hart |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Mechanisms of ageing and development Volume: 48 ISSN: 0047-6374 ISO Abbreviation: Mech. Ageing Dev. Publication Date: 1989 May |
Date Detail:
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Created Date: 1989-08-03 Completed Date: 1989-08-03 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0347227 Medline TA: Mech Ageing Dev Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 117-33 Citation Subset: IM |
Affiliation:
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Department of Health and Human Services, Food and Drug Administration, National Center for Toxicological Research, Jefferson, Arkansas 72079. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Temperature Regulation DNA Damage Energy Intake* Energy Metabolism* Life Expectancy Male Rats Rats, Inbred F344 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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