Document Detail

Effect of chronic antidepressant or electroconvulsive shock treatment on mGLuR1a immunoreactivity expression in the rat hippocampus.
MedLine Citation:
PMID:  10817534     Owner:  NLM     Status:  MEDLINE    
The effect of chronic imipramine (IMI) or electroconvulsive shock (ECS) treatment on the expression of group Ia metabotropic glutamate receptors (mGluR1a) was studied in the rat hippocampus by an immunohistochemical method, using a specific monoclonal antibody. It was found that both those treatments increased the number of mGluR1a immunoreactive neurons in a pyramidal layer of the CA3 hippocampal field. Moreover, IMI, but not ECS, increased the density of mGluR1 a positive neurons in the hilus. The obtained results indicate a possible influence of the antidepressive treatment on the mGluR1a expression in some hippocampal fields.
M Bajkowska; P Brański; M Smiałowska; A Pilc
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Polish journal of pharmacology     Volume:  51     ISSN:  1230-6002     ISO Abbreviation:  Pol J Pharmacol     Publication Date:    1999 Nov-Dec
Date Detail:
Created Date:  2000-06-12     Completed Date:  2000-06-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9313882     Medline TA:  Pol J Pharmacol     Country:  POLAND    
Other Details:
Languages:  eng     Pagination:  539-41     Citation Subset:  IM    
Department of Neurobiology, Institute of Pharmacology, Polish Academy of Sciences, Kraków.
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MeSH Terms
Antidepressive Agents / pharmacology*
Antidepressive Agents, Tricyclic / pharmacology
Electroconvulsive Therapy*
Hippocampus / drug effects*,  metabolism
Imipramine / pharmacology
Pyramidal Cells / drug effects*,  metabolism
Rats, Wistar
Receptors, Metabotropic Glutamate / drug effects*,  metabolism
Reg. No./Substance:
0/Antidepressive Agents; 0/Antidepressive Agents, Tricyclic; 0/Receptors, Metabotropic Glutamate; 0/metabotropic glutamate receptor type 1; 50-49-7/Imipramine

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