Document Detail

Effect of chronic administration of ammonium sulfate on phosphatic stone recurrence.
MedLine Citation:
PMID:  3627318     Owner:  NLM     Status:  MEDLINE    
Urine alkalinization favours the formation of calcium phosphate (CaP) and struvite stones. In this retrospective study we analyze the effect of chronic urinary acidification on phosphatic stone recurrence. Twenty-four patients with CaP-struvite recurrent stones and persistently high urinary pH were divided in two groups: group A, 11 patients who failed to lower the urinary pH below 5.5 during a standard acid load test: group B, 13 patients with preserved acidification power. Ammonium sulfate 2-3 g/day was given for 4.7 and 6.5 years to groups A and B, respectively. A persistent reduction in urinary pH, relative saturation for CaP and stone formation rate was observed in both groups. The treatment did not cause systemic acidosis as long as renal function remained normal. Urinary daily excretion of Ca and P as well as their renal tubular handling did not change with time. Results suggest acidifying agents might be useful in preventing recurrence of CaP-struvite stones even in the presence of a mild acidification defect and encourage undertaking properly controlled prospective trials.
F Pizzarelli; M Peacock
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Nephron     Volume:  46     ISSN:  0028-2766     ISO Abbreviation:  Nephron     Publication Date:  1987  
Date Detail:
Created Date:  1987-10-21     Completed Date:  1987-10-21     Revised Date:  2013-04-05    
Medline Journal Info:
Nlm Unique ID:  0331777     Medline TA:  Nephron     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  247-52     Citation Subset:  IM    
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MeSH Terms
Ammonium Sulfate / administration & dosage*
Calcium Phosphates / metabolism*
Chronic Disease
Drug Evaluation
Hydrogen-Ion Concentration
Kidney Calculi / drug therapy*,  metabolism
Magnesium / metabolism*
Magnesium Compounds*
Middle Aged
Phosphates / metabolism*
Retrospective Studies
Time Factors
Reg. No./Substance:
0/Calcium Phosphates; 0/Magnesium Compounds; 0/Phosphates; 0/alpha-tricalcium phosphate; 0/monocalcium phosphate; 0/tetracalcium phosphate; 15490-91-2/struvite; 7439-95-4/Magnesium; 7783-20-2/Ammonium Sulfate; 97Z1WI3NDX/calcium phosphate; L11K75P92J/dicalcium phosphate anhydrous

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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