Document Detail

Effect of chronic acetazolamide administration on gas exchange and acid-base control after maximal exercise.
MedLine Citation:
PMID:  8005865     Owner:  NLM     Status:  MEDLINE    
The interaction between systems regulating acid-base balance (i.e., CO2, strong ions, week acids) was studied in six subjects for 10 min after 30 s of maximal isokinetic cycling during control conditions (CON) and after 3 days of chronic acetazolamide (ChACZ) administration (500 mg/8 h po) to inhibit carbonic anhydrase (CA). Gas exchange was measured; arterial and venous forearm blood was sampled for acid-base variables. Muscle power output was similar in ChACZ and CON, but peak O2 intake was lower in ChACZ; peak CO2 output was also lower in ChACZ (2,207 +/- 220 ml/min) than in CON (3,238 +/- 87 ml/min). Arterial PCO2 was lower at rest, and its fall after exercise was delayed in ChACZ. In ChACZ there was a higher arterial [Na+] and lower arterial [lactate-] ([La-]) accompanied by lower arterial [K+] and higher arterial [Cl-] during the first part of recovery, resulting in a higher arterial plasma strong ion difference (sigma [cations] - sigma [anions]). Venoarterial (v-a) differences across the forearm showed a similar uptake of Na+, K+, Cl-, and La- in ChACZ and CON. Arterial [H+] was higher and [HCO3-] was lower in ChACZ. Compared with CON, v-a [H+] was similar and v-a [HCO3-] was lower in ChACZ. Chronic CA inhibition impaired the efflux of CO2 from inactive muscle and its excretion by the lungs and also influenced the equilibration of strong ions.(ABSTRACT TRUNCATED AT 250 WORDS)
J M Kowalchuk; G J Heigenhauser; J R Sutton; N L Jones
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  76     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1994 Mar 
Date Detail:
Created Date:  1994-07-15     Completed Date:  1994-07-15     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1211-9     Citation Subset:  IM; S    
Faculty of Kinesiology, University of Western Ontario, London, Canada.
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MeSH Terms
Acetazolamide / pharmacology*
Acid-Base Equilibrium / drug effects*
Acidosis / metabolism
Bicarbonates / blood
Blood Gas Analysis
Carbon Dioxide / blood
Exercise / physiology*
Exercise Test
Hemoglobins / metabolism
Lactates / blood
Oxygen Consumption / drug effects
Plasma Volume / drug effects
Pulmonary Gas Exchange / drug effects*
Sodium / blood
Reg. No./Substance:
0/Bicarbonates; 0/Hemoglobins; 0/Lactates; 124-38-9/Carbon Dioxide; 59-66-5/Acetazolamide; 7440-23-5/Sodium

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