| Effect of chronic Pseudomonas aeruginosa infection on the development of atherosclerosis in a rat model. | |
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MedLine Citation:
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PMID: 15301672 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In order to investigate the possible relationship between atherosclerosis and chronic Pseudomonas aeruginosa infection, 66 Wistar rats were given five separate intratracheal inoculations of either P. aeruginosa or sterile saline at 4-week intervals. The rats were divided into four groups: group 1 was infected with P. aeruginosa and fed a diet containing cholesterol 1% w/v; group 2 was infected with P. aeruginosa and fed a normal diet; group 3 was not infected and was fed a diet containing cholesterol 1% w/v; and group 4 (the control group) was not infected and was fed a normal diet. One month after the final inoculation, the rats were killed humanely; computerised image analysis was used to evaluate sections of the aorta and heart, and the maximal wall thickness of the aorta and coronary artery. The aortic wall thickness was significantly greater for group 1 (329.53 +/- 58.06 microm) compared to groups 2 (190.59 +/- 27.81 microm; p < 0.0001), 3 (262.90 +/- 61.12 microm; p < 0.0004) and 4 (158.00 +/- 30.30 microm; p < 0.0001). Similarly, the coronary artery wall thickness was significantly greater for group 1 (72.96 +/- 10.67 microm) compared to groups 2 (35.07 +/- 8.53 microm; p < 0.0001), 3 (41.45 +/- 10.22 microm; p < 0.0001) and 4 (32.30 +/- 5.27 microm; p < 0.0001). These findings strengthen the hypothesis that chronic infection plays a role in the pathogenesis of atherosclerosis. |
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Authors:
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C Turkay; R Saba; N Sahin; N Pahin; H Altunbas; H Altunbap; O Ozbudak; B Akkaya; G Ozbilim; I Cölbasi; Y Gölbapý; M Turkay; D Ogünc; D Odünç; O Bayezid |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases Volume: 10 ISSN: 1198-743X ISO Abbreviation: Clin. Microbiol. Infect. Publication Date: 2004 Aug |
Date Detail:
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Created Date: 2004-08-10 Completed Date: 2004-10-28 Revised Date: 2006-11-07 |
Medline Journal Info:
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Nlm Unique ID: 9516420 Medline TA: Clin Microbiol Infect Country: France |
Other Details:
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Languages: eng Pagination: 705-8 Citation Subset: IM |
Affiliation:
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Department of Cardiovascular Surgery, Akdeniz University, Antalya, Turkey. turkey@med.akdeniz.edu.tr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arteriosclerosis / etiology*, microbiology, pathology Cholesterol, Dietary / administration & dosage Chronic Disease Disease Models, Animal* Pseudomonas Infections / complications*, microbiology Pseudomonas aeruginosa / isolation & purification Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, Dietary |
| Comments/Corrections | |
Erratum In:
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Clin Microbiol Infect. 2004 Nov;10(11):1036 Note: Pahin, N [corrected to Sahin, N]; Altunbap, H [corrected to Altunbas, H]; Golbapy, Y [corrected to Colbasi, I]; Odunc, D [corrected to Ogunc, D] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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