| Effect of chorioamnionitis on neurodevelopmental outcome in preterm infants. | |
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MedLine Citation:
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PMID: 16275792 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To assess the association of neurodevelopmental outcome with the placental diagnosis of chorioamnionitis in very low-birth-weight infants. METHODS: One hundred seventy-seven surviving very low-birth-weight infants, 22 to 29 weeks' gestational age, born after varying severity of chorioamnionitis, were evaluated at a mean +/- SD age of 19 +/- 6 months' corrected age with Bayley Scales of Infant Development II and neurologic examination. Select maternal and infant variables were abstracted from the medical records. Neonatal morbidities, Mental Developmental Index (MDI) score, Psychomotor Developmental Index (PDI) score, probability of normal MDI and PDI scores (>84), and cerebral palsy between the chorioamnionitis and the control groups were assessed, controlling for gestational age, sex, and the maternal use of steroids and antibiotics. RESULTS: The chorioamnionitis group of 102 infants was compared with 75 control infants (mean +/- SD birth weight, 947 +/- 236 g and 966 +/- 219 g, respectively; mean +/- SD gestational age, 26.1 +/- 2.8 weeks and 27.1 +/- 1.5 weeks, respectively). Infants with chorioamnionitis, compared with controls, had a significantly higher incidence of intraventricular hemorrhage (30% vs 13%) and retinopathy of prematurity (68% vs 42%). Cerebral palsy was diagnosed in 8.6% of the infants with chorioamnionitis and 6.6% of the controls. The MDI and PDI scores were similar between the chorioamnionitis and control groups (mean +/- SD MDI score, 96 +/- 16 vs 97 +/- 18 and mean +/- SD PDI score, 94 +/- 19 vs 92 +/- 19, respectively). CONCLUSIONS: In very low-birth-weight infants we found a higher incidence of intraventricular hemorrhage and retinopathy of prematurity but similar MDI and PDI scores and risk of cerebral palsy associated with chorioamnionitis. |
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Authors:
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Sharadha Polam; Anne Koons; Mujahid Anwar; Susan Shen-Schwarz; Thomas Hegyi |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Archives of pediatrics & adolescent medicine Volume: 159 ISSN: 1072-4710 ISO Abbreviation: Arch Pediatr Adolesc Med Publication Date: 2005 Nov |
Date Detail:
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Created Date: 2005-11-08 Completed Date: 2005-11-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9422751 Medline TA: Arch Pediatr Adolesc Med Country: United States |
Other Details:
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Languages: eng Pagination: 1032-5 Citation Subset: AIM; IM |
Affiliation:
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Division of Neonatology, Department of Pediatrics, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, NJ, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Chorioamnionitis* Female Follow-Up Studies Gestational Age Humans Incidence Infant Infant, Newborn Infant, Premature, Diseases / epidemiology, etiology* Infant, Very Low Birth Weight / growth & development* Male Nervous System / growth & development* Nervous System Diseases / diagnosis*, epidemiology Pregnancy Pregnancy Outcome* Retrospective Studies Risk Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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