Document Detail


Effect of chondroitin sulfate on the biodegradation and drug release of chitosan gel beads in subcutaneous air pouches of mice.
MedLine Citation:
PMID:  11853181     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Chitosan (CS) gel beads were prepared in 10% amino acid solution (pH 9) and modified by forming an electrostatic complex between the amino group of CS and the carboxyl group of chondroitin sulfate (Cho). Modification of the CS gel matrix by Cho inhibited the in vitro release of prednisolone (PS) from the gel beads. CS gel beads modified by Cho (CS-Cho) were implanted into air pouches (AP) prepared subcutaneously on the dorsal surfaces of mice. No inflammatory response was observed. The in vivo release of PS from CS-Cho gel beads and their biodegradation in the AP was slower than beads without Cho treatment. After 28 days of implantation, CS-Cho gel beads (deacetylation of CS: 90%) were still detectable, although they had become softer and smaller. Modification of the CS gel matrix by Cho controls the biodegradation of the beads and the release of the drug. This effect makes these beads a promising biocompatible and biodegradable vehicle for sustained drug delivery.
Authors:
Kyoko Kofuji; Tomohiro Ito; Yoshifumi Murata; Susumu Kawashima
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biological & pharmaceutical bulletin     Volume:  25     ISSN:  0918-6158     ISO Abbreviation:  Biol. Pharm. Bull.     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-02-20     Completed Date:  2002-08-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9311984     Medline TA:  Biol Pharm Bull     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  268-71     Citation Subset:  IM    
Affiliation:
Faculty of Pharmaceutical Sciences, Hokuriku University, Kanazawa, Japan. k-kofuji@hokuriku-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Animals
Biodegradation, Environmental
Chitin / administration & dosage*,  analogs & derivatives
Chitosan
Chondroitin Sulfates / pharmacology*
Drug Delivery Systems*
Gels
Male
Mice
Prednisolone / administration & dosage,  chemistry,  pharmacokinetics
Solubility
Chemical
Reg. No./Substance:
0/Gels; 1398-61-4/Chitin; 50-24-8/Prednisolone; 9007-28-7/Chondroitin Sulfates; 9012-76-4/Chitosan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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