Document Detail


Effect of a cholinergic stimulant on interaction of isoprenaline with beta-adrenoceptors.
MedLine Citation:
PMID:  182504     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The maximum contraction induced in taenia from the guninea pig caecum by a cholinergic stimulant, butyltrimethylammonium (BuTMA) was relaxed by papaverine (10(-4) M) but not by l-isoprenaline (5 X 10(-7) M). The concentrations used relaxed the taenia completely in the absence of BuTMA. BuTMA (10(-4) M) decreased the increase of cyclic AMP caused by isoprenaline but not that due to papaverine. Futhermore, photoinactivation of the beta-adrenoceptors by l-isoprenaline was not observed on the taenia contracted by BuTMA (10(-4) M). These results suggest that l-isoprenaline does nto interact with the beta-adrenoceptors in the taenie contracted by the high concentration of BuTMA.
Authors:
I Takayanagi; N Kondo; K Takagi
Related Documents :
10795784 - Carbohydrate availability affects ammonemia during exercise after beta 2-adrenergic blo...
12105954 - Effect of 1-methylcyclopropene on volatile emission and aroma in cv. anna apples.
22194404 - Walk or run? is high-intensity exercise more effective than moderate intensity exercise...
8256254 - Anticoagulant and estrogenic effects of two new 17 beta-aminoestrogens, butolame [17 be...
12528274 - Sudden death due to recreational exercise in physicians.
21993044 - Building a beverage for recovery from endurance activity: a review.
Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  European journal of pharmacology     Volume:  38     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1976 Jul 
Date Detail:
Created Date:  1976-11-01     Completed Date:  1976-11-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  179-82     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Cecum / drug effects,  metabolism
Cyclic AMP / metabolism
Drug Interactions
Guinea Pigs
Isoproterenol / pharmacology*
Male
Muscle Contraction / drug effects
Parasympathomimetics / pharmacology*
Quaternary Ammonium Compounds / pharmacology
Receptors, Adrenergic / drug effects*
Chemical
Reg. No./Substance:
0/Parasympathomimetics; 0/Quaternary Ammonium Compounds; 0/Receptors, Adrenergic; 60-92-4/Cyclic AMP; 7683-59-2/Isoproterenol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The antagonism of nicotine-induced cardiovascular responses by DMAE and DEO analogs.
Next Document:  Effects of neuroleptic agents on cyclic GMP in rat cerebral cortex.