Document Detail

Effect of a cholinergic stimulant on interaction of isoprenaline with beta-adrenoceptors.
MedLine Citation:
PMID:  182504     Owner:  NLM     Status:  MEDLINE    
The maximum contraction induced in taenia from the guninea pig caecum by a cholinergic stimulant, butyltrimethylammonium (BuTMA) was relaxed by papaverine (10(-4) M) but not by l-isoprenaline (5 X 10(-7) M). The concentrations used relaxed the taenia completely in the absence of BuTMA. BuTMA (10(-4) M) decreased the increase of cyclic AMP caused by isoprenaline but not that due to papaverine. Futhermore, photoinactivation of the beta-adrenoceptors by l-isoprenaline was not observed on the taenia contracted by BuTMA (10(-4) M). These results suggest that l-isoprenaline does nto interact with the beta-adrenoceptors in the taenie contracted by the high concentration of BuTMA.
I Takayanagi; N Kondo; K Takagi
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  European journal of pharmacology     Volume:  38     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1976 Jul 
Date Detail:
Created Date:  1976-11-01     Completed Date:  1976-11-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  179-82     Citation Subset:  IM    
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MeSH Terms
Cecum / drug effects,  metabolism
Cyclic AMP / metabolism
Drug Interactions
Guinea Pigs
Isoproterenol / pharmacology*
Muscle Contraction / drug effects
Parasympathomimetics / pharmacology*
Quaternary Ammonium Compounds / pharmacology
Receptors, Adrenergic / drug effects*
Reg. No./Substance:
0/Parasympathomimetics; 0/Quaternary Ammonium Compounds; 0/Receptors, Adrenergic; 60-92-4/Cyclic AMP; 7683-59-2/Isoproterenol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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