| Effect of cholinergic agonists on muscular tonus of the lizard small intestine and esophagus. | |
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MedLine Citation:
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PMID: 10530339 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The underlying mechanisms of acetylcholine-induced intestinal relaxation in the lizard Liolaemus tenuis tenuis are still unknown. By using a classical model of intestinal recording of isometric contraction and relaxation in conjunction with specific pharmacological tools, this article studies the possible influence of EDRF/NO and nicotinic ganglionar receptors on the Ach-induced relaxation in an effort to elucidate the probable mechanisms involved in ACh effect. It was observed that the relaxation of the lizard intestine elicited by ACh (10(-7) - 4 x 10(-4) M) was not affected by hexametonium (5 x 10(-4) M) or tetrodotoxin (10(-6) M). Nicotine (10(-7) to 10(-4) M) induced relaxation was significantly antagonized by hexametonium; however, it was not influenced by tetrodotoxin. These results allow us to discard a neuronal pathway in cholinergic-induced relaxation, suggesting a more direct cholinergic effect on the smooth muscle, perhaps mediated by an unknown substance released by some specialized tissue. N-nitro-L-arginine, used to block NO-synthase and NO production, induced no changes in ACh-induced relaxation. Methylene blue, a soluble guanylate cyclase inhibitor, induced no changes in ACh-induced relaxation. These results allow us to discard a probable role of EDRF/nitric oxide in the ACh-induced relaxation of lizard small intestine, providing evidence that this mechanism could be different from that reported in other species. |
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Authors:
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J Wacyk; M Fuenzalida; M Morales; O Acuña; D Lemus |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biological research Volume: 32 ISSN: 0716-9760 ISO Abbreviation: Biol. Res. Publication Date: 1999 |
Date Detail:
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Created Date: 1999-12-29 Completed Date: 1999-12-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9308271 Medline TA: Biol Res Country: CHILE |
Other Details:
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Languages: eng Pagination: 29-33 Citation Subset: IM |
Affiliation:
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Institute of Biomedical Sciences (ICBM), Faculty of Medicine, University of Chile, Santiago de Chile. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cholinergic Agonists / pharmacology* Esophagus / drug effects* Female Intestine, Small / drug effects* Lizards Male Muscle Relaxation / drug effects* Muscle Tonus / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Cholinergic Agonists |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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