Document Detail


Effect of cholestyramine and colestipol on the absorption of phenytoin.
MedLine Citation:
PMID:  6873150     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The hypocholesterolemic cation resins, cholestyramine and colestipol, have variable effects on the absorption parameters of a number of lipophillic, anion drugs. Because of the unpredictable nature of this interaction, we have assessed in human volunteers the effect of these resins on the rate and total absorption of phenytoin. Our results indicate that these resins do not affect the absorption parameters of phenytoin and that special care does not have to be exercised when these agents are co-administered.
Authors:
J T Callaghan; M Tsuru; J L Holtzman; D B Hunninghake
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of clinical pharmacology     Volume:  24     ISSN:  0031-6970     ISO Abbreviation:  Eur. J. Clin. Pharmacol.     Publication Date:  1983  
Date Detail:
Created Date:  1983-09-09     Completed Date:  1983-09-09     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  1256165     Medline TA:  Eur J Clin Pharmacol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  675-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Cholestyramine Resin / pharmacology*
Colestipol / pharmacology*
Drug Interactions
Half-Life
Humans
Intestinal Absorption / drug effects*
Male
Phenytoin / metabolism*
Polyamines / pharmacology*
Chemical
Reg. No./Substance:
0/Polyamines; 11041-12-6/Cholestyramine Resin; 50925-79-6/Colestipol; 57-41-0/Phenytoin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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