| Effect of a cholesterol rich diet, recurrent infection and possible treatment modalities on the pulmonary vascular system: an experimental study. | |
| | |
MedLine Citation:
|
PMID: 21942115 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
OBJECTIVE: Infection may lead to inflammation, atherosclerosis and thrombotic vascular events. The atherosclerotic effect of hypercholesterolaemia on the vascular system is well-known. However, limited studies were done on the therapeutic and preventative agents. The aim of this study was to investigate the effects of infection and cholesterol rich diet combined with an antibiotic, anti-inflammatory agent and red wine on the pulmonary vascular system. METHODS: Fifty-nine rats were evaluated. Six groups were created: Control-Group I (n = 10); infection --Group II (n = 9), infection-cholesterol rich diet--Group III (n = 12), infection-cholesterol rich diet-cefepime--Group IV (n = II); infection-cholesterol rich diet-diclofenac potassium--Group V (n = 9); infection-cholesterol rich diet and red wine--Group VI (n = 8). Blood samples of rats were collected for cholesterol analysis every month. Sections of central pulmonary arteries were examined for thickness of the intima and medial wall by computerised image analysis. RESULTS: There was a statistically significant difference in serum cholesterol levels and in thickness of the intima between the groups (p = 0.000). The rest of the groups had more intimal thickening than Group I (p = 0.000). Group III had thicker intima than Groups IV and V (p = 0.009, p = 0.011 respectively). There was no significant difference between the groups in thickness of media (p = 0.432). CONCLUSION: Infection and cholesterol rich diet have a synergistic effect on atherosclerosis in pulmonary arteries. However antibiotics and anti-inflammatory agents could be useful in prevention. |
| | |
Authors:
|
O Ozbudak; I H Ozbudak; C Turkay; N Sahin; S Ozdem; M Turkay; G Ozbilim |
Related Documents
:
|
12612145 - Regulation of sulfur amino acid metabolism in men in response to changes in sulfur amin... 7465515 - Factors affecting efficacy of methionine hydroxy analogue for chicks fed practical diets. 14988455 - The balance of dietary sulfur amino acids and the route of feeding affect plasma homocy... 8987665 - Effects of feeding tryptophan-limiting diets on the conversion ratio of tryptophan to n... 9201745 - Physicochemical characteristics of five date fruit cultivars grown in the united arab e... 2335005 - Comparison of the effects of dietary beef tallow and corn oil on pancreatic carcinogene... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The West Indian medical journal Volume: 60 ISSN: 0043-3144 ISO Abbreviation: West Indian Med J Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-09-27 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0417410 Medline TA: West Indian Med J Country: Jamaica |
Other Details:
|
Languages: eng Pagination: 132-6 Citation Subset: IM |
Affiliation:
|
Department of Pulmonary Medicine, Akdeniz University School of Medicine, Antalya, Turkey. ozbudak@akdeniz.edu.tr |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Dengue HLA associations in Jamaicans.
Next Document: Poverty, folate deficiency, human immunodeficiency virus and ulcerated vulval sexually transmitted d...