Document Detail

Effect of a cholesterol-lowering diet during pregnancy on maternal and fetal Doppler velocimetry: the CARRDIP study.
MedLine Citation:
PMID:  17547890     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The purpose of this study was to evaluate the effect of a low-cholesterol low-saturated fat diet on Doppler indices in the fetus and mother. STUDY DESIGN: Two hundred ninety nonsmoking white women, aged 21-38 years, without previous pregnancy complications and carrying a single fetus were assigned randomly to continue their usual diet (control subjects; n = 149) or to adopt a low-cholesterol low-saturated fat diet (intervention group; n = 141) from gestational week 17-20 to birth. Doppler velocimetry of the umbilical artery and both uterine arteries were assessed at gestational weeks 24, 30, and 36. RESULTS: The physiologic gestational decrease in umbilical artery pulsatility index (PI) from week 24-30 was more pronounced in the intervention group, compared with the control group, with median values (interquartile range) of -0.17 (-0.29, -0.06) and -0.11 (-0.25, 0.01), respectively (P = .048). Assignment to the intervention diet did not influence the changes in mean PI value of the 2 uterine arteries (P = .3). The change in umbilical artery PI and mean PI value of the uterine arteries between weeks 24 and 36 were not significantly different between the 2 groups (P = 1.0 and .2 respectively). CONCLUSION: Our study shows that a cholesterol-lowering diet during pregnancy may modify fetoplacental circulation in mid pregnancy.
Janette Khoury; Guttorm Haugen; Serena Tonstad; Kathrine Frey Frøslie; Tore Henriksen
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  196     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-06-05     Completed Date:  2007-10-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  549.e1-7     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, Rikshospitalet-Radiumhospitalet Medical Center, Oslo, Norway.
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MeSH Terms
Antigens / blood
Blood Flow Velocity
Cholesterol, Dietary / administration & dosage*
Cholesterol, LDL / blood
Diet, Carbohydrate-Restricted*
Dyslipidemias / prevention & control
Fetal Blood
Placental Circulation
Pulsatile Flow
Tissue Plasminogen Activator / blood,  immunology
Ultrasonography, Doppler, Color
Ultrasonography, Prenatal
Umbilical Arteries / ultrasonography*
Uterus / blood supply*,  ultrasonography*
Reg. No./Substance:
0/Antigens; 0/Cholesterol, Dietary; 0/Cholesterol, LDL; EC Plasminogen Activator
Comment In:
Am J Obstet Gynecol. 2007 Jun;196(6):497-8   [PMID:  17547872 ]

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