Document Detail


Effect of a cholecystokinin preparation on brain monoamines in the rat.
MedLine Citation:
PMID:  7463880     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In order to elucidate the central action mechanism of cholecystokinin (CCK), effects of this peptide on norepinephrine, dopamine and serotonin contents in the brain were observed in saline control, alpha-methyl-p-tyrosine-, L-DOPA- and pargyline-pretreated rats. Intraperitoneal injection of CCK in a dose of 40 U/kg did not produce any significant changes in the monoamine contents. However, since a tendency to increase in norepinephrine turnover rate after CCK injection was noticed, the possibility that brain monoamines are involved in the central action of CCK could not be excluded.
Authors:
G Katsuura; R Hirota; S Itoh
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Japanese journal of physiology     Volume:  30     ISSN:  0021-521X     ISO Abbreviation:  Jpn. J. Physiol.     Publication Date:  1980  
Date Detail:
Created Date:  1981-04-21     Completed Date:  1981-04-21     Revised Date:  2007-03-21    
Medline Journal Info:
Nlm Unique ID:  2985184R     Medline TA:  Jpn J Physiol     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  811-4     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain / metabolism*
Cholecystokinin / pharmacology*
Dopamine / metabolism*
Dose-Response Relationship, Drug
Levodopa / pharmacology
Male
Methyltyrosines / pharmacology
Norepinephrine / metabolism*
Pargyline / pharmacology
Rats
Serotonin / metabolism*
Chemical
Reg. No./Substance:
0/Levodopa; 0/Methyltyrosines; 50-67-9/Serotonin; 51-41-2/Norepinephrine; 555-57-7/Pargyline; 9011-97-6/Cholecystokinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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