Document Detail

Effect of a cholecystokinin preparation on brain monoamines in the rat.
MedLine Citation:
PMID:  7463880     Owner:  NLM     Status:  MEDLINE    
In order to elucidate the central action mechanism of cholecystokinin (CCK), effects of this peptide on norepinephrine, dopamine and serotonin contents in the brain were observed in saline control, alpha-methyl-p-tyrosine-, L-DOPA- and pargyline-pretreated rats. Intraperitoneal injection of CCK in a dose of 40 U/kg did not produce any significant changes in the monoamine contents. However, since a tendency to increase in norepinephrine turnover rate after CCK injection was noticed, the possibility that brain monoamines are involved in the central action of CCK could not be excluded.
G Katsuura; R Hirota; S Itoh
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Japanese journal of physiology     Volume:  30     ISSN:  0021-521X     ISO Abbreviation:  Jpn. J. Physiol.     Publication Date:  1980  
Date Detail:
Created Date:  1981-04-21     Completed Date:  1981-04-21     Revised Date:  2007-03-21    
Medline Journal Info:
Nlm Unique ID:  2985184R     Medline TA:  Jpn J Physiol     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  811-4     Citation Subset:  IM    
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MeSH Terms
Brain / metabolism*
Cholecystokinin / pharmacology*
Dopamine / metabolism*
Dose-Response Relationship, Drug
Levodopa / pharmacology
Methyltyrosines / pharmacology
Norepinephrine / metabolism*
Pargyline / pharmacology
Serotonin / metabolism*
Reg. No./Substance:
0/Levodopa; 0/Methyltyrosines; 50-67-9/Serotonin; 51-41-2/Norepinephrine; 555-57-7/Pargyline; 9011-97-6/Cholecystokinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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