| Effect of cholecystokinin octapeptide on body temperature in the rat. | |
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MedLine Citation:
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PMID: 6804679 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The C-terminal octapeptide of cholecystokinin (CCK-8) injected into the lateral ventricle of rats produced a lowering of body temperature. CCK-8 potentiated pentobarbital-induced hypothermia, but not the ethanol one. Thyrotropin releasing hormone (TRH) and prostaglandin E2 (PGE2) antagonized the hypothermic effect of CCK-8. Non-sulfated CCK-8 was ineffective in lowering body temperature, indicating that sulfated tyrosine in the CCK molecule is indispensable for its hypothermic action. Caerulein was found to possess rather less activity compared with CCK-8. |
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Authors:
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G Katsuura; S Itoh |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Japanese journal of physiology Volume: 31 ISSN: 0021-521X ISO Abbreviation: Jpn. J. Physiol. Publication Date: 1981 |
Date Detail:
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Created Date: 1982-07-08 Completed Date: 1982-07-08 Revised Date: 2007-03-21 |
Medline Journal Info:
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Nlm Unique ID: 2985184R Medline TA: Jpn J Physiol Country: JAPAN |
Other Details:
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Languages: eng Pagination: 849-58 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Temperature Regulation / drug effects* Caerulein / pharmacology Cholecystokinin / administration & dosage, antagonists & inhibitors, pharmacology* Dinoprostone Ethanol / pharmacology Injections, Intraventricular Male Pentobarbital / pharmacology Prostaglandins E / pharmacology Rats Thyrotropin-Releasing Hormone / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Prostaglandins E; 17650-98-5/Caerulein; 24305-27-9/Thyrotropin-Releasing Hormone; 363-24-6/Dinoprostone; 64-17-5/Ethanol; 76-74-4/Pentobarbital; 9011-97-6/Cholecystokinin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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