Document Detail

Effect of cholecystokinin on meal size and intermeal interval in the sham-feeding rat.
MedLine Citation:
PMID:  690290     Owner:  NLM     Status:  MEDLINE    
After 3-hr food deprivation, rats with gastric fistulas ate liquid food with the fistula closed (normal feeding) or open (sham feeding). Meal size (MS) was larger, latency to rest (LR) after a meal was longer, and intermeal interval (IMI) was shorter during sham feeding than during normal feeding. The putative satiety signal cholecystokinin (CCK, 20% pure) decreased MS and LR and increased IMI during sham feeding. After CCK (30 U/kg) the MS, LR, and IMI were the same during sham feeding as during normal feeding. The synthetic octapeptide (OCT) of CCK, which has the known biological actions of the complete hormone, reproduced the effects of CCK (30 U/kg) on MS and LR but not on IMI. Ingestive behavior was not nonspecifically suppressed by CCK or OCT because water drinking was not inhibited by CCK or OCT. The CCK and OCT were also tested for their ability to serve as unconditioned stimuli (UCS) for the formation of a conditioned taste aversion (CTA) in the 3-hr food-deprived sham-feeding rat. The OCT (30 U/kg) did not serve as a UCS for a CTA in the same sham-feeding conditions in which OCT produced normal MS and LR. Impure CCK (30 U/kg), however, did serve as a UCS for a CTA under these conditions. The differential effectiveness of CCK and OCT for IMI and CTA may be due to non-CCK factors in the impure extract of CCK. These experiments demonstrate that the preabsorptive food-contingent stimuli of sham feeding plus exogenous CCK are sufficient for normal short-term satiety under certain conditions, and they provide further evidence consistent with the hypothesis that cholecystokinin produces satiety in rats.
F S Kraly; W J Carty; S Resnick; G P Smith
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of comparative and physiological psychology     Volume:  92     ISSN:  0021-9940     ISO Abbreviation:  J Comp Physiol Psychol     Publication Date:  1978 Aug 
Date Detail:
Created Date:  1978-12-02     Completed Date:  1978-12-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0414612     Medline TA:  J Comp Physiol Psychol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  697-707     Citation Subset:  IM    
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MeSH Terms
Cholecystokinin / pharmacology*
Dose-Response Relationship, Drug
Feeding Behavior / drug effects*
Reaction Time
Satiation / drug effects*
Satiety Response / drug effects*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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