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Effect of cholecalciferol overdosage on pregnancy outcome in white albino mice.
MedLine Citation:
PMID:  23209973     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Irrational prescription and use of vitamins is rife in our society today. This practice is very common among pregnant women without adequate need assessment and concern for over dosage. Cholecalciferol has remained a component of some routine antenatal drugs despite the fears that have been expressed concerning its safety.
OBJECTIVES: This study was set to determine the effect of cholecalciferol over dosage on pregnancy outcome in white albino mice.
METHOD: High doses of vitamin D were given to three groups of female white albino mice from the day copulation plugs were seen. A fourth group was given normal saline as control. Drug exposure period was 22 days. Parameters studied included number of litters per delivery, average weight and length of the litters.
RESULTS: The oral LD(50) was 9,747 IU/kg. No death occurred during teratogenic studies. There was statistically significant reduction in the number of litters delivered by animals given medium (1200 IU) and high (1800 IU) doses compared to controls (P=0.041 and 0.0002 respectively). Their litters also had reduced average length and weight (P =0.0001).
CONCLUSION: High doses of vitamin D negatively affected pregnancy outcome in white albino mice.
Authors:
Jo Ogamba; Po Ughachukwu; Ec Ezema
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of medical and health sciences research     Volume:  1     ISSN:  2141-9248     ISO Abbreviation:  Ann Med Health Sci Res     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2012-12-04     Completed Date:  2012-12-10     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  101585351     Medline TA:  Ann Med Health Sci Res     Country:  Nigeria    
Other Details:
Languages:  eng     Pagination:  181-6     Citation Subset:  -    
Affiliation:
Department of Pharmacology and Therapeutics College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria.
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