Document Detail

Effect of chlorpromazine on intracellular transport of phospholipids.
MedLine Citation:
PMID:  7460078     Owner:  NLM     Status:  MEDLINE    
The transfer of phosphatidylinositol from rat liver microsomes to liposomes stimulated by cytoplasmic protein was found to be inhibited by the addition of chlorpromazine, while the phosphatidylcholine transfer was not affected. The administration of chlorpromazine has been shown to enhance the synthetic rate of phosphatidylinositol and is assumed from the present experiment to decrease the intracellular transfer rate, leading to the accumulation of phosphatidylinositol in the endoplasmic reticulum. On the other hand, chlorpromazine caused the depression of the secretion of phosphatidylcholine to the blood plasma. Thus, the phospholipid composition of rat liver endoplasmic reticulum seems to remain unchanged by the balance of the intracellular alterations of phospholipid metabolism.
H Ide; Y Nakazawa
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Chemico-biological interactions     Volume:  34     ISSN:  0009-2797     ISO Abbreviation:  Chem. Biol. Interact.     Publication Date:  1981 Feb 
Date Detail:
Created Date:  1981-04-24     Completed Date:  1981-04-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0227276     Medline TA:  Chem Biol Interact     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  69-73     Citation Subset:  IM    
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MeSH Terms
Biological Transport / drug effects
Chlorpromazine / pharmacology*
Microsomes, Liver / metabolism
Phospholipids / blood,  metabolism*
Subcellular Fractions / metabolism*
Reg. No./Substance:
0/Liposomes; 0/Phospholipids; 50-53-3/Chlorpromazine

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