Document Detail


Effect of chloroquine in experimental myocardial ischaemia.
MedLine Citation:
PMID:  3227859     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The cardiac effects of the phospholipase A2 inhibiting agent chloroquine were studied in dogs, rats and cats. During left anterior descending coronary artery occlusion produced in anaesthetized mongrel dog, chloroquine pretreatment considerably reduced the epicardial ST-segment elevation in the ischaemic area, as well as the number of premature ventricular contractions. In conscious male Sprague-Dawley CFY rats it diminished the duration and prolonged the latency of appearance of the early post-infarction arrhythmias and increased the survival rate following coronary artery ligation. Chloroquine failed to affect the ventricular fibrillation threshold in the normoxic cat heart. The cardioprotective action of chloroquine could be explained at least partly by its antiphospholipase activity.
Authors:
T Fazekas; L Szekeres
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta physiologica Hungarica     Volume:  72     ISSN:  0231-424X     ISO Abbreviation:  Acta Physiol Hung     Publication Date:  1988  
Date Detail:
Created Date:  1989-03-27     Completed Date:  1989-03-27     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8309201     Medline TA:  Acta Physiol Hung     Country:  HUNGARY    
Other Details:
Languages:  eng     Pagination:  191-9     Citation Subset:  IM    
Affiliation:
First Department of Medicine, University Medical School, Szeged, Hungary.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / drug effects
Chloroquine / therapeutic use*
Coronary Disease / drug therapy,  physiopathology*
Dogs
Fatty Acids, Nonesterified / blood
Heart / drug effects,  physiopathology
Male
Myocardial Contraction / drug effects
Rats
Rats, Inbred Strains
Chemical
Reg. No./Substance:
0/Fatty Acids, Nonesterified; 54-05-7/Chloroquine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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