Document Detail


Effect of chloroquine adsorption on acid reactivity of magnesium trisilicate.
MedLine Citation:
PMID:  14246     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Due to the adsorption of chloroquine by magnesium trisilicate, both the BP acid absorption test and the rate of hydrochloric acid uptake, as monitored by pH measurements, were significantly reduced. This reduction was dependent on the amount of chloroquine adsorbed, since multilayer adsorption produced relatively more suppressive effects than did monolayer adsorption. The presence of adsorbed chloroquine also decreased the amounts of magnesium released in an acid medium. The inhibition of the antacid property due to chloroquine adsorption may be attributed to the occupation of the reactive sites of the antacid surface by chloroquine and to a reduction of the surface of the antacid due to flocculation of the particles.
Authors:
S A Khalil
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pharmaceutical sciences     Volume:  66     ISSN:  0022-3549     ISO Abbreviation:  J Pharm Sci     Publication Date:  1977 Feb 
Date Detail:
Created Date:  1977-04-15     Completed Date:  1977-04-15     Revised Date:  2000-12-18    
Medline Journal Info:
Nlm Unique ID:  2985195R     Medline TA:  J Pharm Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  289-90     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adsorption
Antacids*
Chemistry, Pharmaceutical
Chloroquine*
Hydrochloric Acid
Hydrogen-Ion Concentration
Magnesium
Nephelometry and Turbidimetry
Silicic Acid*
Silicon Dioxide*
Time Factors
Chemical
Reg. No./Substance:
0/Antacids; 1343-98-2/Silicic Acid; 54-05-7/Chloroquine; 7439-95-4/Magnesium; 7631-86-9/Silicon Dioxide; 7647-01-0/Hydrochloric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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