| Effect of chloroquine adsorption on acid reactivity of magnesium trisilicate. | |
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MedLine Citation:
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PMID: 14246 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Due to the adsorption of chloroquine by magnesium trisilicate, both the BP acid absorption test and the rate of hydrochloric acid uptake, as monitored by pH measurements, were significantly reduced. This reduction was dependent on the amount of chloroquine adsorbed, since multilayer adsorption produced relatively more suppressive effects than did monolayer adsorption. The presence of adsorbed chloroquine also decreased the amounts of magnesium released in an acid medium. The inhibition of the antacid property due to chloroquine adsorption may be attributed to the occupation of the reactive sites of the antacid surface by chloroquine and to a reduction of the surface of the antacid due to flocculation of the particles. |
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Authors:
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S A Khalil |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of pharmaceutical sciences Volume: 66 ISSN: 0022-3549 ISO Abbreviation: J Pharm Sci Publication Date: 1977 Feb |
Date Detail:
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Created Date: 1977-04-15 Completed Date: 1977-04-15 Revised Date: 2000-12-18 |
Medline Journal Info:
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Nlm Unique ID: 2985195R Medline TA: J Pharm Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 289-90 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adsorption Antacids* Chemistry, Pharmaceutical Chloroquine* Hydrochloric Acid Hydrogen-Ion Concentration Magnesium Nephelometry and Turbidimetry Silicic Acid* Silicon Dioxide* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Antacids; 1343-98-2/Silicic Acid; 54-05-7/Chloroquine; 7439-95-4/Magnesium; 7631-86-9/Silicon Dioxide; 7647-01-0/Hydrochloric Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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