| Effect of chlorhexidine varnish application on mutans streptococci counts in orthodontic patients. | |
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MedLine Citation:
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PMID: 18331945 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: Enamel demineralization occurs frequently around orthodontic brackets. High levels of mutans streptococci (MS) increase the risk of caries. The hypotheses tested in this study were that high-frequency application of 40% chlorhexidine varnish (40%CHX) results in lower levels of MS in plaque of orthodontic patients compared with low-frequency application, and that bimonthly application of 40%CHX results in lower levels of MS in plaque compared with 1% chlorhexidine/1% thymol varnish (1%CHX). METHODS: Eighty adolescent patients were randomly allocated to 4 treatment groups: monthly, bimonthly, and quarterly 40%CHX application, and bimonthly application of 1%CHX. Plaque samples were collected monthly and processed for MS counts. Twenty patients dropped out before the evaluation time at 1 month. Data from the remaining 60 adolescents were analyzed by using linear regression models with the plaque bacterial ratio (PBRx) as the dependent variable. The trial was ended after 5 months because of a high number of dropouts. RESULTS: High-frequency application of 40%CHX did not provide lower mean PBRx than low-frequency application. Mean PBRx after 40%CHX application was lower than 1%CHX after 1 month (P = .002). This reduction was undiscernible 2 months after the application. CONCLUSIONS: 40%CHX application results in greater reduction of MS in plaque than 1%CHX a month after application. A follow-up study with a larger study population is warranted to test the first hypothesis. |
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Authors:
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Aniek Derks; Jo Frencken; Ewald Bronkhorst; Anne Marie Kuijpers-Jagtman; Christos Katsaros |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics Volume: 133 ISSN: 1097-6752 ISO Abbreviation: Am J Orthod Dentofacial Orthop Publication Date: 2008 Mar |
Date Detail:
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Created Date: 2008-03-11 Completed Date: 2008-03-25 Revised Date: 2010-07-22 |
Medline Journal Info:
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Nlm Unique ID: 8610224 Medline TA: Am J Orthod Dentofacial Orthop Country: United States |
Other Details:
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Languages: eng Pagination: 435-9 Citation Subset: D; IM |
Affiliation:
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Department of Orthodontics and Oral Biology, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Anti-Infective Agents, Local / adverse effects* Child Chlorhexidine / administration & dosage* Colony Count, Microbial Dental Caries / etiology, microbiology, prevention & control* Dental Plaque / microbiology Dose-Response Relationship, Drug Drug Administration Schedule Drug Combinations Humans Linear Models Orthodontic Brackets / adverse effects Pilot Projects Streptococcus mutans / drug effects* Thymol / administration & dosage |
| Chemical | |
Reg. No./Substance:
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0/Anti-Infective Agents, Local; 0/Drug Combinations; 0/EC40 dental varnish; 0/chlorhexidine, thymol drug combination; 55-56-1/Chlorhexidine; 89-83-8/Thymol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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