Document Detail

Effect of chlorhexidine varnish application on mutans streptococci counts in orthodontic patients.
MedLine Citation:
PMID:  18331945     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Enamel demineralization occurs frequently around orthodontic brackets. High levels of mutans streptococci (MS) increase the risk of caries. The hypotheses tested in this study were that high-frequency application of 40% chlorhexidine varnish (40%CHX) results in lower levels of MS in plaque of orthodontic patients compared with low-frequency application, and that bimonthly application of 40%CHX results in lower levels of MS in plaque compared with 1% chlorhexidine/1% thymol varnish (1%CHX). METHODS: Eighty adolescent patients were randomly allocated to 4 treatment groups: monthly, bimonthly, and quarterly 40%CHX application, and bimonthly application of 1%CHX. Plaque samples were collected monthly and processed for MS counts. Twenty patients dropped out before the evaluation time at 1 month. Data from the remaining 60 adolescents were analyzed by using linear regression models with the plaque bacterial ratio (PBRx) as the dependent variable. The trial was ended after 5 months because of a high number of dropouts. RESULTS: High-frequency application of 40%CHX did not provide lower mean PBRx than low-frequency application. Mean PBRx after 40%CHX application was lower than 1%CHX after 1 month (P = .002). This reduction was undiscernible 2 months after the application. CONCLUSIONS: 40%CHX application results in greater reduction of MS in plaque than 1%CHX a month after application. A follow-up study with a larger study population is warranted to test the first hypothesis.
Aniek Derks; Jo Frencken; Ewald Bronkhorst; Anne Marie Kuijpers-Jagtman; Christos Katsaros
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics     Volume:  133     ISSN:  1097-6752     ISO Abbreviation:  Am J Orthod Dentofacial Orthop     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-03-11     Completed Date:  2008-03-25     Revised Date:  2010-07-22    
Medline Journal Info:
Nlm Unique ID:  8610224     Medline TA:  Am J Orthod Dentofacial Orthop     Country:  United States    
Other Details:
Languages:  eng     Pagination:  435-9     Citation Subset:  D; IM    
Department of Orthodontics and Oral Biology, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands.
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MeSH Terms
Anti-Infective Agents, Local / adverse effects*
Chlorhexidine / administration & dosage*
Colony Count, Microbial
Dental Caries / etiology,  microbiology,  prevention & control*
Dental Plaque / microbiology
Dose-Response Relationship, Drug
Drug Administration Schedule
Drug Combinations
Linear Models
Orthodontic Brackets / adverse effects
Pilot Projects
Streptococcus mutans / drug effects*
Thymol / administration & dosage
Reg. No./Substance:
0/Anti-Infective Agents, Local; 0/Drug Combinations; 0/EC40 dental varnish; 0/chlorhexidine, thymol drug combination; 55-56-1/Chlorhexidine; 89-83-8/Thymol

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