| Effect of chemotherapy on ascorbate and ascorbyl radical in cerebrospinal fluid and serum of acute lymphoblastic leukemia. | |
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MedLine Citation:
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PMID: 11156482 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ascorbyl radical (ASR) in human cerebrospinal fluid (CSF) of various patients using electron paramagnetic resonance (EPR) at ambient temperature was investigated. Also, effect of chemotherapy on ASR as well as ascorbate (ASA) in CSF and serum of acute lymphoblastic leukemia (ALL) was studied. EPR spectra of various CSF samples showed a characteristic doublet, which was attributed to ASR. ASR in CSF and serum was directly measured without any chemical modification. ASA and ASR concentration in CSF were approximately two times higher than those in serum. ASA and ASR concentrations in CSF and serum were statistically analyzed. The analyses showed that ASR and ASA in CSF and serum had good correlation for patients undergoing chemotherapy but not for patients after the therapy. The correlation for ASR and ASA suggests that ascorbate may play an important role during chemotherapy. In addition, dynamic aspects of ASA and ASR in CSF and serum are discussed. |
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Authors:
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K Nakagawa |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cellular and molecular biology (Noisy-le-Grand, France) Volume: 46 ISSN: 0145-5680 ISO Abbreviation: Cell. Mol. Biol. (Noisy-le-grand) Publication Date: 2000 Dec |
Date Detail:
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Created Date: 2001-01-11 Completed Date: 2001-03-29 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9216789 Medline TA: Cell Mol Biol (Noisy-le-grand) Country: France |
Other Details:
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Languages: eng Pagination: 1375-81 Citation Subset: IM |
Affiliation:
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Radio Isotope Research Center, Fukushima Medical University, Hikarigaoka, Japan. nakagawa@fmu.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Antineoplastic Agents / pharmacokinetics Ascorbic Acid / blood*, cerebrospinal fluid* Child Child, Preschool Dehydroascorbic Acid / analogs & derivatives*, blood*, cerebrospinal fluid* Electron Spin Resonance Spectroscopy / methods* Female Humans Male Middle Aged Models, Chemical Precursor Cell Lymphoblastic Leukemia-Lymphoma / blood*, cerebrospinal fluid*, drug therapy* Temperature |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 490-83-5/Dehydroascorbic Acid; 50-81-7/Ascorbic Acid; 6730-29-6/semidehydroascorbic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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