Document Detail

Effect of a chemotherapeutic agent delivered by an oral irrigation device on plaque, gingivitis, and subgingival microflora.
MedLine Citation:
PMID:  2674395     Owner:  NLM     Status:  MEDLINE    
Sixty-six adults were examined in a double-bind study which examined the effect of an antimicrobial agent delivered by an oral irrigating device. Each subject received a randomized half mouth dental prophylaxis. The Gingival Index, gingival crevicular fluid volume, Plaque Index, Modified Papillary Bleeding Index, probing pocket depth, and probing attachment levels were determined at baseline, 3 weeks, and 6 weeks. The composition of the subgingival microflora in the prophied and non-prophied quadrants was examined by phase contrast microscopy and by immunofluorescence. This study demonstrates that an antimicrobial product delivered by an oral irrigating device could result in significant reductions in plaque, bacterial cell counts, and gingival bleeding and may, therefore, be an effective adjunct to normal oral hygiene.
S G Ciancio; M L Mather; J J Zambon; H S Reynolds
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of periodontology     Volume:  60     ISSN:  0022-3492     ISO Abbreviation:  J. Periodontol.     Publication Date:  1989 Jun 
Date Detail:
Created Date:  1989-10-25     Completed Date:  1989-10-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8000345     Medline TA:  J Periodontol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  310-5     Citation Subset:  D; IM    
Department of Periodontology, School of Dental Medicine, State University of New York, Buffalo.
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MeSH Terms
Anti-Infective Agents, Local / administration & dosage*,  therapeutic use
Bacteria / drug effects,  isolation & purification*
Dental Plaque / microbiology,  prevention & control*
Dental Prophylaxis / instrumentation
Double-Blind Method
Drug Combinations / administration & dosage,  therapeutic use
Gingiva / microbiology
Gingival Crevicular Fluid
Gingival Hemorrhage / prevention & control
Gingivitis / prevention & control*
Irrigation / instrumentation*
Mouthwashes / administration & dosage*,  therapeutic use
Pilot Projects
Salicylates / administration & dosage,  therapeutic use
Terpenes / administration & dosage,  therapeutic use
Reg. No./Substance:
0/Anti-Infective Agents, Local; 0/Drug Combinations; 0/Mouthwashes; 0/Salicylates; 0/Terpenes; 51273-66-6/Listerine

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