Document Detail

Effect of chemical enhancers on percutaneous absorption of daphnetin in isopropyl myristate vehicle across rat skin in vitro.
MedLine Citation:
PMID:  19280376     Owner:  NLM     Status:  MEDLINE    
The percutaneous absorption properties of daphnetin with chemical penetration enhancers were investigated to explore the feasibility of daphnetin as a candidate for transdermal delivery to treat arthritis. Permeation experiments were carried out in vitro using 2-chamber diffusion cells in isopropyl myristate (IPM) vehicle using rat abdominal skin as a barrier. Various enhancers were employed, including O-acylmenthol derivatives synthesized in the laboratory and many conventional enhancers. Among the O-acylmenthol derivatives, 2-isopropyl-5-methylcyclohexyl 2-hydroxypanoate (M-LA) demonstrated a significant enhancing effect on daphnetin permeation. The highest degree of enhancement was obtained when NMP combined with Span 80 and the cumulative transport was 667.29 microg/cm(2) over 8 h. The solubility parameters, vehicle/stratum corneum partition, and diffusion coefficients were calculated to clarify the enhancing mechanism of classic enhancers on daphnetin. In conclusion, these findings allow a rational approach for designing an effective daphnetin transdermal delivery system.
Ziyi Wen; Liang Fang; Zhonggui He
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Drug delivery     Volume:  16     ISSN:  1521-0464     ISO Abbreviation:  Drug Deliv     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-06-24     Completed Date:  2009-11-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9417471     Medline TA:  Drug Deliv     Country:  England    
Other Details:
Languages:  eng     Pagination:  214-23     Citation Subset:  IM    
Department of Pharmaceutical Sciences, Shenyang Pharmaceutical University, Liaoning, PR China.
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MeSH Terms
Administration, Cutaneous
Anesthetics, Local / administration & dosage
Chemistry, Pharmaceutical
Drug Carriers / chemistry
Drug Delivery Systems
Myristates / metabolism*
Rats, Wistar
Skin / drug effects,  metabolism*
Skin Absorption
Umbelliferones / chemistry,  metabolism*
Vehicles / administration & dosage,  chemistry
Reg. No./Substance:
0/Anesthetics, Local; 0/Drug Carriers; 0/Myristates; 0/Umbelliferones; 0/Vehicles; 110-27-0/isopropyl myristate; 486-35-1/daphnetin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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