| Effect of chemical enhancers on percutaneous absorption of daphnetin in isopropyl myristate vehicle across rat skin in vitro. | |
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MedLine Citation:
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PMID: 19280376 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The percutaneous absorption properties of daphnetin with chemical penetration enhancers were investigated to explore the feasibility of daphnetin as a candidate for transdermal delivery to treat arthritis. Permeation experiments were carried out in vitro using 2-chamber diffusion cells in isopropyl myristate (IPM) vehicle using rat abdominal skin as a barrier. Various enhancers were employed, including O-acylmenthol derivatives synthesized in the laboratory and many conventional enhancers. Among the O-acylmenthol derivatives, 2-isopropyl-5-methylcyclohexyl 2-hydroxypanoate (M-LA) demonstrated a significant enhancing effect on daphnetin permeation. The highest degree of enhancement was obtained when NMP combined with Span 80 and the cumulative transport was 667.29 microg/cm(2) over 8 h. The solubility parameters, vehicle/stratum corneum partition, and diffusion coefficients were calculated to clarify the enhancing mechanism of classic enhancers on daphnetin. In conclusion, these findings allow a rational approach for designing an effective daphnetin transdermal delivery system. |
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Authors:
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Ziyi Wen; Liang Fang; Zhonggui He |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Drug delivery Volume: 16 ISSN: 1521-0464 ISO Abbreviation: Drug Deliv Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-06-24 Completed Date: 2009-11-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9417471 Medline TA: Drug Deliv Country: England |
Other Details:
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Languages: eng Pagination: 214-23 Citation Subset: IM |
Affiliation:
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Department of Pharmaceutical Sciences, Shenyang Pharmaceutical University, Liaoning, PR China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Cutaneous Anesthetics, Local / administration & dosage Animals Chemistry, Pharmaceutical Drug Carriers / chemistry Drug Delivery Systems Male Myristates / metabolism* Rats Rats, Wistar Skin / drug effects, metabolism* Skin Absorption Solubility Umbelliferones / chemistry, metabolism* Vehicles / administration & dosage, chemistry |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Local; 0/Drug Carriers; 0/Myristates; 0/Umbelliferones; 0/Vehicles; 110-27-0/isopropyl myristate; 486-35-1/daphnetin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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