Document Detail


Effect of the chaotropic anions thiocyanate and perchlorate on the entry of ricin into Vero cells.
MedLine Citation:
PMID:  2990449     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of different anions on the sensitivity of Vero cells to ricin was investigated. The cells were equally sensitive to ricin when NaCl was replaced by NaBr, NaI, Na2SO4 or with iso-osmotic concentrations of mannitol. In contrast, NaSCN and NaClO4 strongly protected against ricin at pH 7.2, but not at pH 7.6. The possibility that the protective effect is due to the ability of chaotropic anions to decrease the pH close to the membrane is discussed.
Authors:
K Sandvig; S Olsnes
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Biochemical journal     Volume:  228     ISSN:  0264-6021     ISO Abbreviation:  Biochem. J.     Publication Date:  1985 Jun 
Date Detail:
Created Date:  1985-08-21     Completed Date:  1985-08-21     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2984726R     Medline TA:  Biochem J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  521-3     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Anions / pharmacology
Cell Line
Haplorhini
Hydrogen-Ion Concentration
Kidney
Perchloric Acid / pharmacology*
Ricin / metabolism*
Sodium Compounds*
Thiocyanates / pharmacology*
Chemical
Reg. No./Substance:
0/Anions; 0/Sodium Compounds; 0/Thiocyanates; 540-72-7/sodium thiocyanate; 7601-89-0/sodium perchlorate; 7601-90-3/Perchloric Acid; 9009-86-3/Ricin
Comments/Corrections

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