Document Detail

Effect of the chaotropic anions thiocyanate and perchlorate on the entry of ricin into Vero cells.
MedLine Citation:
PMID:  2990449     Owner:  NLM     Status:  MEDLINE    
The effect of different anions on the sensitivity of Vero cells to ricin was investigated. The cells were equally sensitive to ricin when NaCl was replaced by NaBr, NaI, Na2SO4 or with iso-osmotic concentrations of mannitol. In contrast, NaSCN and NaClO4 strongly protected against ricin at pH 7.2, but not at pH 7.6. The possibility that the protective effect is due to the ability of chaotropic anions to decrease the pH close to the membrane is discussed.
K Sandvig; S Olsnes
Related Documents :
8616789 - Near-hexaploid ph-positive acute myeloid leukemia with major-bcr/abl transcript.
3101769 - Bcr-abl rna in patients with chronic myelogenous leukemia.
18036399 - Confirmation of a novel recurrent association: bcr-abl t(9;22) and t(19;21).
10526539 - Fluorescence in situ hybridization analysis of complex translocations in two newly diag...
3289649 - The abl oncogene in human leukemias.
3115029 - T(1;2), inv(1) and trisomy 1q during the blastic phase of philadelphia chromosome-posit...
11238419 - The length of the intact donor chromosome segment around a target gene in marker-assist...
648179 - Murine ovarian teratomas and parthenotes as cytogenetic tools.
20832309 - Genetics, chromatin diminution, and sex chromosome evolution in the parasitic nematode ...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Biochemical journal     Volume:  228     ISSN:  0264-6021     ISO Abbreviation:  Biochem. J.     Publication Date:  1985 Jun 
Date Detail:
Created Date:  1985-08-21     Completed Date:  1985-08-21     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2984726R     Medline TA:  Biochem J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  521-3     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anions / pharmacology
Cell Line
Hydrogen-Ion Concentration
Perchloric Acid / pharmacology*
Ricin / metabolism*
Sodium Compounds*
Thiocyanates / pharmacology*
Reg. No./Substance:
0/Anions; 0/Sodium Compounds; 0/Thiocyanates; 540-72-7/sodium thiocyanate; 7601-89-0/sodium perchlorate; 7601-90-3/Perchloric Acid; 9009-86-3/Ricin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Inhibition of hydroxyapatite formation in collagen gels by chondroitin sulphate.
Next Document:  Modification of opioid ligand binding in the central and the peripheral nervous system by different ...