Document Detail

Effect of changes in ventricular relaxation on early diastolic coronary blood flow in canine hearts.
MedLine Citation:
PMID:  3664979     Owner:  NLM     Status:  MEDLINE    
Since the gradient between aortic pressure and left ventricular diastolic pressure is a major determinant of coronary blood flow, a change in left ventricular relaxation by its effect on early diastole could diminish early diastolic coronary flow. Two interventions that resulted in impaired left ventricular relaxation, hypothermia, and reperfusion following a left anterior descending coronary artery occlusion were studied to evaluate whether there were associated changes in coronary blood flow. With both interventions, there was a significant prolongation of left ventricular relaxation (p less than 0.01) accompanied by a significant decrease in early diastolic coronary blood flow (p less than 0.01). Verapamil did not have a significant effect on these hemodynamic changes during hypothermia. However, verapamil significantly blunted the effects of reperfusion following ischemia on ventricular relaxation (p less than 0.002) and early diastolic coronary blood flow (p less than 0.01). Thus, impaired left ventricular relaxation has an adverse impact on early diastolic coronary blood flow, which, under the condition of reperfusion following regional myocardial ischemia, can be alleviated with calcium channel blockade.
L J Domalik-Wawrzynski; W J Powell; L Guerrero; I Palacios
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Circulation research     Volume:  61     ISSN:  0009-7330     ISO Abbreviation:  Circ. Res.     Publication Date:  1987 Nov 
Date Detail:
Created Date:  1987-12-11     Completed Date:  1987-12-11     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0047103     Medline TA:  Circ Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  747-56     Citation Subset:  IM    
Cardiac Unit, Massachusetts General Hospital, Boston 02114.
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MeSH Terms
Coronary Circulation* / drug effects
Coronary Disease / physiopathology
Coronary Vessels / physiopathology
Heart Ventricles / physiopathology
Hypothermia / physiopathology
Myocardial Contraction* / drug effects
Verapamil / pharmacology
Grant Support
1-R01-HL29817-2/HL/NHLBI NIH HHS; 5-P50-HL26215/HL/NHLBI NIH HHS; 5-T32-HL07208/HL/NHLBI NIH HHS
Reg. No./Substance:

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